Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1372-5
Abstract: The caged xanthone gambogic acid (GA) is a novel anti-cancer agent which exhibits anti-proliferative, anti-inflammatory and cytotoxic effects in many types of cancer tissues. In a recent phase IIa study, GA exhibits a favourable safety…
read more here.
Keywords:
kir2;
kir2 kir2;
pip2;
inhibition ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1918387117
Abstract: Significance Ion channels form pores that allow for the selective transport of ions across cell membranes, generating electrical signals in response to a variety of signals. Inward rectifier potassium (Kir) channels in particular are regulated…
read more here.
Keywords:
kir2;
rectifier potassium;
lipid species;
membrane ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0177600
Abstract: Arrhythmogenesis in acute myocardial infarction (MI) is associated with depolarization of resting membraine potential (RMP) and decrease of inward rectifier potassium current (IK1) in cardiomyocytes. However, clinical anti-arrhythmic agents that primarily act on RMP by…
read more here.
Keywords:
kir2;
acute ischemic;
prevents cures;
ischemic arrhythmias ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
2
Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1136272
Abstract: Sildenafil (Viagra), the first approved and widely used oral drug for the treatment of erectile dysfunction, was occasionally associated with life-threatening ventricular arrhythmias in patients. Since inward rectifier potassium current (I K1) may considerably contribute…
read more here.
Keywords:
kir2 kir2;
effect;
kir2;
sildenafil ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.01070
Abstract: The inward rectifying potassium channel, Kir2.1, is selected as cargo at the trans-Golgi network (TGN) for export to the cell surface through a unique signal-dependent interaction with the AP1 clathrin-adaptor, but it is unknown how…
read more here.
Keywords:
kir2;
cos cells;
potassium channel;
channel ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
2
Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.812572
Abstract: Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias. Congenital and acquired KIR2.1 malfunction frequently associates with aberrant ion channel…
read more here.
Keywords:
kir2 forward;
inward rectifier;
kir2;
cytoskeleton ... See more keywords
Sign Up to like & get
recommendations!
2
Published in 2023 at "Acta biochimica et biophysica Sinica"
DOI: 10.3724/abbs.2023083
Abstract: The inwardly rectifying potassium channel Kir2.1 is closely associated with many cardiovascular diseases. However, the effect and mechanism of Kir2.1 in diabetic cardiomyopathy remain unclear. In vivo, we use STZ to establish the model, and…
read more here.
Keywords:
myocardial fibrosis;
tgf smad;
activation kir2;
kir2 ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2022 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2022.5175
Abstract: The investigation of effective therapeutic drugs for pulmonary hypertension (PH) is critical. KIR2.1 plays crucial roles in regulating cell proliferation and migration, and vascular remodeling. However, researchers have not yet clearly determined whether KIR2.1 participates…
read more here.
Keywords:
kir2;
proliferation migration;
migration;
cell proliferation ... See more keywords