Astrocytic Kir4.1 channels regulate locomotion by orchestrating neuronal rhythmicity in the spinal network
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DOI: 10.1002/glia.24337
Abstract: Neuronal rhythmogenesis in the spinal cord is correlated with variations in extracellular K+ levels ([K+]e). Astrocytes play important role in [K+]e homeostasis and compute neuronal information. Yet it is unclear how neuronal oscillations are regulated… read more here.
Keywords: locomotion; rhythmicity spinal; neuronal rhythmicity; kir4 channels ... See more keywords
Metabotropic glutamate receptor 5‐mediated inhibition of inward‐rectifying K+ channel 4.1 contributes to orofacial ectopic mechanical allodynia following inferior alveolar nerve transection in male mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25181
Abstract: Inward‐rectifying K+ channel 4.1 (Kir4.1), which regulates the electrophysiological properties of neurons and glia by affecting K+ homeostasis, plays a critical role in neuropathic pain. Metabotropic glutamate receptor 5 (mGluR5) regulates the expression of Kir4.1… read more here.
Keywords: orofacial ectopic; allodynia; mechanical allodynia; ectopic mechanical ... See more keywords
Persistent Overexposure to N-Methyl-d-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes
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DOI: 10.1007/s12640-018-9958-3
Abstract: Astrocytes express N-methyl-d-aspartate (NMDA) receptor (NMDAR) but its functions in these cells are not well defined. This study shows that the sustained exposure (8–72 h) of mouse astrocytes to NMDA decreases the expression of the functional… read more here.
Keywords: methyl aspartate; glutamine synthetase; kir4; aspartate nmda ... See more keywords
Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.10.023
Abstract: Kir4.1 in the distal convoluted tubule plays a key role in sensing plasma potassium and in modulating the thiazide-sensitive sodium-chloride cotransporter (NCC). Here we tested whether dietary potassium intake modulates Kir4.1 and whether this is… read more here.
Keywords: potassium; distal convoluted; kir4; potassium intake ... See more keywords
Kir4.1 deletion prevents salt-sensitive hypertension in early streptozotocin-induced diabetic mice via Na+–Cl− cotransporter in the distal convoluted tubule
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000003419
Abstract: Objectives: Functional impairment of renal sodium handling and blood pressure (BP) homeostasis is an early characteristic manifestation of type 1 diabetes. However, the underlying mechanisms remain unclear. Methods: Metabolic cages, radio-telemetry, immunoblotting, and electrophysiology were… read more here.
Keywords: stz; hypertension; distal convoluted; activity ... See more keywords
Deciphering the mechanism of calcineurin inhibitor‐induced hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13976
Abstract: In the current issue of Acta Physiologica, Gao et al. explore the possible role of the inward rectifying potassium channel (Kir) 4.1 in cyclosporin Ainduced hyperkalemic hypertension.1 Calcineurin inhibitors, such as cyclosporin A and tacrolimus,… read more here.
Keywords: potassium; calcineurin; calcineurin inhibitors; activity ... See more keywords
Absence of antibodies against KIR4.1 in multiple sclerosis: A three-technique approach and systematic review
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DOI: 10.1371/journal.pone.0175538
Abstract: Introduction Antibodies targeting the inward-rectifying potassium channel KIR4.1 have been associated with multiple sclerosis (MS) but studies using diverse techniques have failed to replicate this association. The detection of these antibodies is challenging; KIR4.1 glycosylation… read more here.
Keywords: systematic review; kir4; association; multiple sclerosis ... See more keywords
Spinal astrocytic MeCP2 regulates Kir4.1 for the maintenance of chronic hyperalgesia in neuropathic pain
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DOI: 10.2139/ssrn.4191251
Abstract: Astrocyte activation in the spinal dorsal horn may play an important role in the development of chronic neuropathic pain, but the mechanisms involved in astrocyte activation and their modulatory effects remain unknown. The inward rectifying… read more here.
Keywords: hyperalgesia; neuropathic pain; kir4; pain ... See more keywords
Modulation of Glutamate Transporter EAAT1 and Inward-Rectifier Potassium Channel Kir4.1 Expression in Cultured Spinal Cord Astrocytes by Platinum-Based Chemotherapeutics
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22126300
Abstract: Platinum-based chemotherapeutics still play an essential role in cancer treatment. Despite their high effectiveness, severe side effects such as chemotherapy-induced neuropathy (CIPN) occur frequently. The pathophysiology of CIPN by platinum-based chemotherapeutics is not fully understood… read more here.
Keywords: cord astrocytes; platinum based; kir4; based chemotherapeutics ... See more keywords