Astrocytic Kir4.1 channels regulate locomotion by orchestrating neuronal rhythmicity in the spinal network
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DOI: 10.1002/glia.24337
Abstract: Neuronal rhythmogenesis in the spinal cord is correlated with variations in extracellular K+ levels ([K+]e). Astrocytes play important role in [K+]e homeostasis and compute neuronal information. Yet it is unclear how neuronal oscillations are regulated… read more here.
Keywords: locomotion; rhythmicity spinal; neuronal rhythmicity; kir4 channels ... See more keywords
Chloroquine blocks the Kir4.1 channels by an open‐pore blocking mechanism
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DOI: 10.1016/j.ejphar.2017.02.024
Abstract: ABSTRACT Kir4.1 channels have been implicated in various physiological processes, mainly in the K+ homeostasis of the central nervous system and in the control of glial function and neuronal excitability. Even though, pharmacological research of… read more here.
Keywords: blocks kir4; mechanism; pharmacology; chloroquine ... See more keywords
Kir4.1 channels in NG2-glia play a role in development, potassium signaling, and ischemia-related myelin loss
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DOI: 10.1038/s42003-018-0083-x
Abstract: The contribution of the inwardly rectifying K+ channel subtype Kir4.1 has been focused mainly on astrocytes, where they play important roles in the maintenance of resting membrane potential, extracellular K+ uptake, and facilitation of glutamate… read more here.
Keywords: kir4 channels; channels ng2; ng2 glia; development potassium ... See more keywords
Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats
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DOI: 10.3390/ijms20051013
Abstract: The dysfunction of astrocytic inwardly rectifying potassium (Kir) 4.1 channels, which mediate the spatial potassium-buffering function of astrocytes, is known to be involved in the development of epilepsy. Here, we analyzed the Kir4.1 expressional changes… read more here.
Keywords: astrocytic kir4; epileptogenesis; mutant rats; kir4 channels ... See more keywords
Emerging Roles of Astrocyte Kir4.1 Channels in the Pathogenesis and Treatment of Brain Diseases
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DOI: 10.3390/ijms221910236
Abstract: Inwardly rectifying Kir4.1 channels in astrocytes mediate spatial potassium (K+) buffering, a clearance mechanism for excessive extracellular K+, in tripartite synapses. In addition to K+ homeostasis, astrocytic Kir4.1 channels also play an essential role in… read more here.
Keywords: astrocytic kir4; brain diseases; kir4 channels; brain ... See more keywords