Activation of Kir4.1/Kir5.1 contributes to the cyclosporin A‐induced stimulation of the renal NaCl cotransporter and hyperkalemic hypertension
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DOI: 10.1111/apha.13948
Abstract: Cyclosporin A (CsA) is a widely used immunosuppressive drug that causes hypertension and hyperkalemia. Moreover, CsA‐induced stimulation of the thiazide‐sensitive NaCl cotransporter (NCC) in the kidney has been shown to be responsible for the development… read more here.
Keywords: hypertension; hyperkalemic hypertension; nacl cotransporter; induced stimulation ... See more keywords
Deciphering the mechanism of calcineurin inhibitor‐induced hypertension
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DOI: 10.1111/apha.13976
Abstract: In the current issue of Acta Physiologica, Gao et al. explore the possible role of the inward rectifying potassium channel (Kir) 4.1 in cyclosporin Ainduced hyperkalemic hypertension.1 Calcineurin inhibitors, such as cyclosporin A and tacrolimus,… read more here.
Keywords: potassium; calcineurin; calcineurin inhibitors; activity ... See more keywords
Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter
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DOI: 10.1172/jci.insight.165987
Abstract: We examine whether calcineurin or protein phosphatase 2B (PP2B) regulates the basolateral inwardly rectifying potassium channel Kir4.1/Kir5.1 in the distal convoluted tubule (DCT). Application of tacrolimus (FK506) or cyclosporine A (CsA) increased whole-cell Kir4.1/Kir5.1-mediated K+… read more here.
Keywords: kir4 kir5; dct; kir5 distal; mice ... See more keywords
The effect of high-dietary K+ (HK) on Kir4.1/Kir5.1 and ROMK in the distal convoluted tubule (DCT) is not affected by gender and Cl− content of the diet
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DOI: 10.3389/fphys.2022.1039029
Abstract: Basolateral potassium channels in the distal convoluted tubule (DCT) are composed of inwardly-rectifying potassium channel 4.1 (Kir4.1) and Kir5.1. Kir4.1 interacts with Kir5.1 to form a 40 pS K+ channel which is the only type… read more here.
Keywords: kir4 kir5; romk; dct; mice ... See more keywords
EAST/SeSAME Syndrome and Beyond: The Spectrum of Kir4.1- and Kir5.1-Associated Channelopathies
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DOI: 10.3389/fphys.2022.852674
Abstract: In 2009, two groups independently linked human mutations in the inwardly rectifying K+ channel Kir4.1 (gene name KCNJ10) to a syndrome affecting the central nervous system (CNS), hearing, and renal tubular salt reabsorption. The autosomal… read more here.
Keywords: kir4 kir5; east sesame; sesame syndrome; physiology ... See more keywords