Kir6.1/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson’s disease via promoting mitophagy
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.07.009
Abstract: ATP-sensitive potassium (K-ATP) channels, coupling cell metabolism to cell membrane potential, are involved in brain diseases, including Parkinson's disease (PD). Kir6.1, a pore-forming subunit of K-ATP channel, is prominently expressed in astrocytes and participates in… read more here.
Keywords: kir6 atp; astrocytic kir6; atp channel; kir6 ... See more keywords
Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurotrauma"
DOI: 10.1089/neu.2018.5986
Abstract: Abstract In severe traumatic brain injury (TBI), contusions often are worsened by contusion expansion or hemorrhagic progression of contusion (HPC), which may double the original contusion volume and worsen outcome. In humans and rodents with… read more here.
Keywords: trpm4; contusion; kir6; sur1 trpm4 ... See more keywords
SUR1/Kir6.2 potassium channel a new actor involved in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2020.3561
Abstract: Background: Recently mutations in ABBC8 have been identified in patients with pulmonary arterial hypertension (PAH). ABCC8 encodes SUR1 a regulatory subunit of the ATP-sensitive potassium channel Kir6.2. In 2018, Bohnen M et al., demonstrated that… read more here.
Keywords: kir6; pulmonary arterial; sur1 kir6; hypertension ... See more keywords