Placental protein expression of kisspeptin-1 (KISS1) and the kisspeptin-1 receptor (KISS1R) in pregnancy complicated by diabetes mellitus or preeclampsia
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DOI: 10.1007/s00404-019-05408-1
Abstract: Purpose Kisspeptins regulate the trophoblast invasion. The disturbance of this process might lead to the development of preeclampsia (PE). Diabetes mellitus (DM) is associated with the high rate of this complication. The main hypothesis was… read more here.
Keywords: protein expression; placental protein; kiss1; expression kisspeptin ... See more keywords
MiR-199-3p modulates the onset of puberty in rodents probably by regulating the expression of Kiss1 via the p38 MAPK pathway
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DOI: 10.1016/j.mce.2020.110994
Abstract: The Kiss1 gene plays an indispensable role in modulating the onset of puberty and fertility in mammals. Although an increasing number of genetic and environmental factors that influence reproduction through Kiss1 have been identified, the… read more here.
Keywords: kiss1; p38 mapk; expression; expression kiss1 ... See more keywords
Gonadotropin secretion and ovarian response of KISS1 knockout gilts treated with hormone analogs activating the hypothalamic-pituitary-gonadal axis†.
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DOI: 10.1093/biolre/ioaf174
Abstract: Kisspeptin knockout (KISS1-/-) pigs exhibit hypogonadotropic hypogonadism. Hormone analogs targeting different levels of the hypothalamic-pituitary-gonad axis were used to characterize the secretion of reproductive hormones (LH and FSH) and ovarian responses (estradiol and progesterone) in… read more here.
Keywords: hypothalamic pituitary; kiss1 gilts; gonadotropin secretion; kiss1 ... See more keywords
Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion.
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DOI: 10.1093/hmg/ddaa215
Abstract: Knockout mice for the kisspeptin receptor, Kiss1r, (Kiss1r-/-) and its ligand kisspeptin, Kiss1, (Kiss1-/-) replicate the phenotype of isolated hypogonadotropic hypogonadism (IHH) associated with variants of these genes in humans. A recent report suggests that… read more here.
Keywords: kiss1; steroid hormone; mice; hormone secretion ... See more keywords
Sexually dimorphic distribution of Kiss1 neurons in the bed nucleus of the stria terminalis
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DOI: 10.1111/jne.70049
Abstract: Kiss1 neurons play a crucial role in reproductive function and are found in distinct brain regions, including the bed nucleus of the stria terminalis (BNST). However, the sexual dimorphism of Kiss1 neurons in the BNST… read more here.
Keywords: distribution; kiss1 neurons; nucleus stria; sexually dimorphic ... See more keywords
Testosterone supplementation rescues spermatogenesis and in vitro fertilizing ability of sperm in Kiss1 knockout mice.
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DOI: 10.1210/endocr/bqaa092
Abstract: Restoration of spermatogenesis and fertility is a major issue to be solved in male mammals with hypogonadotropic hypogonadism. Kiss1 knockout (KO) male mice are postulated to be a suitable animal model to investigate if hormonal… read more here.
Keywords: kiss1; spermatogenesis; testosterone supplementation; mice ... See more keywords
MON-149 Dissecting The Roles Of Kiss1Avpv Neurons In The Control Of Puberty, LH Secretion And Ovulation By Functional Genomics
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DOI: 10.1210/jendso/bvaf149.1886
Abstract: Abstract Disclosure: J. Garcia-Vera: None. F. Ruiz-Pino: None. A. Barroso-Romero: None. C. Torres-Granados: None. S. Daza-Dueñas: None. S. Leon: None. F. Gaytan: None. D. Garcia-Galiano: None. M. Tena-Sempere: None. Kisspeptins (Kp), encoded by Kiss1 gene,… read more here.
Keywords: ovulation; none; kiss1avpv neurons; avpv ... See more keywords
Altered expression of kisspeptin, dynorphin, and related neuropeptides in polycystic ovary syndrome: A cross-sectional study
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DOI: 10.18502/ijrm.v22i5.16440
Abstract: Abstract Background Since kisspeptin (KISS1) in the hypothalamus is affected by the inhibitory effect of dynorphin, it raises questions about the controlled balance of these 2 neuropeptides in women with and without polycystic ovary syndrome… read more here.
Keywords: polycystic ovary; group; pcos; expression ... See more keywords
Increased serum levels of KiSS1-derived peptides in non-small cell lung cancer patient liquid biopsies and biological relevance
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DOI: 10.21037/tlcr-22-52
Abstract: Background The secreted products of the metastasis suppressor gene KiSS1 may represent useful biomarkers in non-small cell lung cancer (NSCLC) but their levels in patients have remained poorly investigated. We previously found that forced expression… read more here.
Keywords: lung cancer; cell; kiss1 derived; kiss1 ... See more keywords
Reversibility and safety of KISS1 metastasis suppressor gene vaccine in immunocastration of ram lambs
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DOI: 10.5713/ajas.17.0629
Abstract: Objective The aim of this study was to investigate the reversibility and safety of KISS1 metastasis suppressor (KISS1) gene vaccine in immunocastration. Methods Six eight-week old ram lambs were randomly divided into vaccinated and control… read more here.
Keywords: kiss1; gene vaccine; ram lambs; primary immunization ... See more keywords