A phase II study of combination daunorubicin, cytarabine (Ara‐c), and nilotinib (TAsigna) (DATA) in patients newly diagnosed with acute myeloid leukemia with KIT expression
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26831
Abstract: Acute myeloid leukemia (AML) is a challenging cancer in terms of achieving and maintaining long‐duration remissions. Many novel therapies have been added to the standard regimen (combining cytarabine and anthracycline “7 + 3”) to achieve such goals.… read more here.
Keywords: myeloid leukemia; kit; cytarabine; acute myeloid ... See more keywords
DNA methylation profile in patients with indolent systemic mastocytosis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12074
Abstract: Abstract Background Mastocytosis is a clinically heterogeneous, usually acquired disease of the mast cells with a survival time that depends on the onset of the disease and ranges from skin‐limited to systemic disease, including indolent… read more here.
Keywords: methylation; methylation profile; kit; dna methylation ... See more keywords
Developmental validation of the Yfiler Platinum PCR Amplification Kit for forensic genetic caseworks and databases
Sign Up to like & getrecommendations! Published in 2020 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202000187
Abstract: Y chromosome kits are successfully applied in cases where human biological material exists. With the development of genotyping ability, more Y chromosomal markers are needed for finer identification of male individuals and lineages. In this… read more here.
Keywords: validation yfiler; kit; developmental validation; forensic genetic ... See more keywords
Quantitative characterization of human oncogene promoter G‐quadruplex DNA‐ligand interactions using a combination of mass spectrometry and capillary electrophoresis
Sign Up to like & getrecommendations! Published in 2021 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202100077
Abstract: Human c‐KIT oncogene is known to regulate cell growth and proliferation, and thus, acts as a probable target in the treatment of gastrointestinal tumors (GIST). To identify small molecule ligands which can specifically bind with… read more here.
Keywords: capillary electrophoresis; combination; oncogene; mass spectrometry ... See more keywords
Development and validation of a forensic multiplex InDel assay: The AGCU InDel 60 kit
Sign Up to like & getrecommendations! Published in 2022 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202100376
Abstract: Marker sets based on insertion/deletion polymorphisms (InDels) combine the characteristics of both short tandem repeats (STRs) and single nucleotide polymorphisms and have served as effective complementary or stand‐alone systems for human identification in forensics. We… read more here.
Keywords: development validation; agcu indel; kit; validation forensic ... See more keywords
Ovarian germ cell tumor/mastocytosis with KIT mutation: A unique clinicopathological entity
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.1002/gcc.23000
Abstract: Most tumors are sporadic and originated from somatic mutations. Some rare germline mutations cause familial tumors, often involving multiple tissues or organs. Tumors from somatic mosaicism during embryonic development are extremely rare. We describe here… read more here.
Keywords: ovarian germ; kit; germ; germ cell ... See more keywords
FGFR2::TACC2 fusion as a novel KIT‐independent mechanism of targeted therapy failure in a multidrug‐resistant gastrointestinal stromal tumor
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23030
Abstract: Genetic alterations in FGF/FGFR pathway are infrequent in gastrointestinal stromal tumors (GIST), with rare cases of quadruple wildtype GISTs harboring FGFR1 gene fusions and mutations. Additionally, FGF/FGFR overexpression was shown to promote drug resistance to… read more here.
Keywords: tacc2 fusion; fusion; kit; multidrug resistant ... See more keywords
Selective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle‐ and exosome‐like populations of KIT‐containing extracellular vesicles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12272
Abstract: Abstract Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient cells.… read more here.
Keywords: human mast; immunocapture; extracellular vesicles; kit ... See more keywords
Comparison of COVID‐19 laboratory diagnosis by commercial kits: Effectivity of RT‐PCR to the RT‐LAMP
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27559
Abstract: Coronavirus disease 2019 or COVID‐19 caused by novel coronavirus/severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 or 2019‐nCoV) is an ongoing pandemic that has emerging global effects and requires rapid and reliable diagnostic testing. Quantitative reverse… read more here.
Keywords: kit; positivity; lamp; diagnosis ... See more keywords
Influence of commercial DNA extraction kit choice on prokaryotic community metrics in marine sediment
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DOI: 10.1002/lom3.10264
Abstract: Commercial DNA extraction kits are widely used for cultivation-free surveys of marine sediment. However, the consequences of popular extraction-kit choices for sequence-based biological inferences about marine sedimentary communities have not previously been exhaustively assessed. To… read more here.
Keywords: extraction; dna; oceanography; limnology ... See more keywords
Regulation of Kit Expression in Early Mouse Embryos and ES Cells
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DOI: 10.1002/stem.2960
Abstract: Kit is a growth factor receptor that regulates proliferation and/or survival of many embryonic and postnatal stem cell types. When mutated, it can induce malignant transformation of the host cells. To dissect the Kit role… read more here.
Keywords: egfp expression; kit; expression; expression early ... See more keywords