CT texture analysis can be a potential tool to differentiate gastrointestinal stromal tumors without KIT exon 11 mutation.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2018.07.025
Abstract: OBJECTIVE To evaluate CT texture analysis as a tool to differentiate gastrointestinal stromal tumors (GISTs) without KIT exon 11 mutation. MATERIALS AND METHODS This study consisted of a study group of 69 GISTs and a… read more here.
Keywords: kit exon; without kit; exon mutation;
KIT Exon 9-Mutated Gastrointestinal Stromal Tumours: Biology and Treatment
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DOI: 10.1159/000521751
Abstract: Background: The majority of gastroinstestinal stromal tumours (GISTs) harbour oncogenic mutations in the gene encoding for the tyrosine kinase (TK) KIT. The most common mutations are found in exon 11, followed by mutations in exon… read more here.
Keywords: kit exon; exon mutant; mutant gists; biology ... See more keywords
INSIGHT: A phase 3, randomized, open-label study of ripretinib vs sunitinib in patients with advanced gastrointestinal stromal tumor previously treated with imatinib with KIT exon 11 + 17/18 mutations.
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DOI: 10.1200/jco.2024.42.3_suppl.tps767
Abstract: TPS767 Background: Gastrointestinal stromal tumor (GIST) is the most common gastrointestinal sarcoma with approximately 80% of cases driven by KIT mutations. Most patients (pts) with advanced GIST experience disease progression following first-line treatment with imatinib… read more here.
Keywords: exon mutations; kit; advanced gist; ripretinib sunitinib ... See more keywords
Molecular Portrait of GISTs Associated With Clinicopathological Features: A Retrospective Study With Molecular Analysis by a Custom 9-Gene Targeted Next-Generation Sequencing Panel
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DOI: 10.3389/fgene.2022.864499
Abstract: Objectives: The study aims to investigate genetic characterization of molecular targets and clinicopathological features with gastrointestinal stromal tumors based on targeted next-generation sequencing. Materials and Methods: We selected 106 patients with GISTs from Sir Run… read more here.
Keywords: gist; kit exon; clinicopathological features; mutation ... See more keywords