c-Kit inhibitors for unresectable or metastatic mucosal, acral or chronically sun-damaged melanoma: a systematic review and one-arm meta-analysis.
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DOI: 10.1016/j.ejca.2021.08.015
Abstract: BACKGROUND Activating genomic alterations of the receptor tyrosine kinase KIT are found preferentially in certain melanoma subtypes such as acral and mucosal melanoma or melanoma arising in chronically sun-damaged skin. However, the therapeutic value of… read more here.
Keywords: melanoma; mucosal; sun damaged; kit ... See more keywords
Response Criteria in Advanced Systemic Mastocytosis: Evolution in the Era of KIT Inhibitors
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DOI: 10.3390/ijms22062983
Abstract: Systemic mastocytosis (SM) is a rare clonal hematologic neoplasm, driven, in almost all cases, by the activating KIT D816V mutation that leads to the growth and accumulation of neoplastic mast cells. While patients with advanced… read more here.
Keywords: response criteria; systemic mastocytosis; response; kit inhibitors ... See more keywords
Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure–Activity Relationship (SAR)
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DOI: 10.3390/ijms24119450
Abstract: The proto-oncogenic protein, c-KIT, plays a crucial role in regulating cellular transformation and differentiation processes, such as proliferation, survival, adhesion, and chemotaxis. The overexpression of, and mutations, in c-KIT can lead to its dysregulation and… read more here.
Keywords: small molecule; kit; stromal tumors; molecule kit ... See more keywords