Discovery of a highly selective KIT kinase primary V559D mutant inhibitor for gastrointestinal stromal tumors (GISTs)
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DOI: 10.18632/oncotarget.22624
Abstract: KIT kinase V559D mutation is the most prevalent primary gain-of-function mutation in Gastrointestinal Stromal Tumors (GISTs). Here we reported a highly selective KIT V559D inhibitor CHMFL-KIT-031, which displayed about 10-20 fold selectivity over KIT wt… read more here.
Keywords: kit kinase; v559d; gastrointestinal stromal; stromal tumors ... See more keywords