Pediatric acute myeloid leukemia with t(8;21) and KIT mutation treatment with avapritinib post-stem cell transplantation: a report of four cases
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Hematology"
DOI: 10.1007/s00277-024-05810-z
Abstract: Acute myeloid leukemia (AML) with t(8;21) (q22;q22), which forms RUNX1::RUNX1T1 fusion gene, is classified as a favorable-risk group. However, the presence of mutations in KIT exon 17 results in an adverse prognosis in this group.… read more here.
Keywords: kit mutation; treatment; stem cell; acute myeloid ... See more keywords
A new monoclonal antibody that blocks dimerisation and inhibits c-kit mutation-driven tumour growth
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03490-6
Abstract: Imatinib, a small-molecule tyrosine kinase inhibitor, has shown good clinical activity by inhibiting adenosine triphosphate (ATP) binding to the receptor. Unfortunately, majority of patients eventually develop drug resistance, which limits the long-term benefits of the… read more here.
Keywords: inhibits kit; kit; kit dimer; dimerisation ... See more keywords
Avapritinib for the treatment of KIT mutation–negative systemic mastocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2022.2123661
Abstract: Abstract Systemic mastocytosis results from the spread of abnormal mast cells in different parts of the body, with variable clinical presentation. It is difficult to diagnose and to determine the appropriate therapy regimen. We present… read more here.
Keywords: mastocytosis; mutation negative; systemic mastocytosis; kit mutation ... See more keywords
Cutaneous hyperpigmentation and familial gastrointestinal stromal tumour associated with KIT mutation
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DOI: 10.1111/ced.13757
Abstract: Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours arising in the gastrointestinal tract. Early detection, before metastasis occurs, is important as complete surgical excision achieves cure. Approximately 85% of GISTs are associated with mutations in the… read more here.
Keywords: cutaneous hyperpigmentation; hyperpigmentation; gastrointestinal stromal; gist ... See more keywords
Novel KIT mutation presenting as marked lentiginosis
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DOI: 10.1111/pde.13952
Abstract: Although lentigines are usually benign, they can be associated with a number of genetic syndromes in which neoplasms and other multi‐system pathological processes occur. Here, we report the case of a 6‐year‐old girl who presented… read more here.
Keywords: novel kit; mutation presenting; kit; presenting marked ... See more keywords
Prognostic Impacts of D816V KIT Mutation and Peri-Transplant RUNX1–RUNX1T1 MRD Monitoring on Acute Myeloid Leukemia with RUNX1–RUNX1T1
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13020336
Abstract: Simple Summary Acute myeloid leukemia (AML) with RUNX1-RUNX1T1 is a heterogeneous disease entailing different prognoses. Patients with high-risk features can benefit from allogeneic hematopoietic stem cell transplantation (HSCT) or autologous HSCT. However, insufficient data about… read more here.
Keywords: d816v kit; mrd; runx1; runx1 runx1t1 ... See more keywords