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Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03490-6
Abstract: Imatinib, a small-molecule tyrosine kinase inhibitor, has shown good clinical activity by inhibiting adenosine triphosphate (ATP) binding to the receptor. Unfortunately, majority of patients eventually develop drug resistance, which limits the long-term benefits of the…
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Keywords:
inhibits kit;
kit;
kit dimer;
dimerisation ... See more keywords
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Published in 2022 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2022.2123661
Abstract: Abstract Systemic mastocytosis results from the spread of abnormal mast cells in different parts of the body, with variable clinical presentation. It is difficult to diagnose and to determine the appropriate therapy regimen. We present…
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Keywords:
mastocytosis;
mutation negative;
systemic mastocytosis;
kit mutation ... See more keywords
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Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13757
Abstract: Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours arising in the gastrointestinal tract. Early detection, before metastasis occurs, is important as complete surgical excision achieves cure. Approximately 85% of GISTs are associated with mutations in the…
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Keywords:
cutaneous hyperpigmentation;
hyperpigmentation;
gastrointestinal stromal;
gist ... See more keywords
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Published in 2019 at "Pediatric Dermatology"
DOI: 10.1111/pde.13952
Abstract: Although lentigines are usually benign, they can be associated with a number of genetic syndromes in which neoplasms and other multi‐system pathological processes occur. Here, we report the case of a 6‐year‐old girl who presented…
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Keywords:
novel kit;
mutation presenting;
kit;
presenting marked ... See more keywords
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Published in 2021 at "Cancers"
DOI: 10.3390/cancers13020336
Abstract: Simple Summary Acute myeloid leukemia (AML) with RUNX1-RUNX1T1 is a heterogeneous disease entailing different prognoses. Patients with high-risk features can benefit from allogeneic hematopoietic stem cell transplantation (HSCT) or autologous HSCT. However, insufficient data about…
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Keywords:
d816v kit;
mrd;
runx1;
runx1 runx1t1 ... See more keywords