Nintedanib overcomes drug resistance from upregulation of FGFR signaling and imatinib-induced KIT mutations in gastrointestinal stromal tumors.
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DOI: 10.1002/1878-0261.13199
Abstract: Drug resistance remains a major challenge in the clinical treatment of gastrointestinal stromal tumors (GISTs). While acquired on-target mutations of mast/stem cell growth factor receptor (KIT) kinase is the major resistance mechanism, activation of alternative… read more here.
Keywords: imatinib; stromal tumors; kit mutations; resistance ... See more keywords
Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors.
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DOI: 10.1021/acs.jmedchem.2c00851
Abstract: The treatment of gastrointestinal stromal tumors (GISTs) driven by activating mutations in the KIT gene is a prime example of targeted therapy for treatment of cancer. The approval of the tyrosine kinase inhibitor imatinib has… read more here.
Keywords: stromal tumors; kit; inhibitor; treatment ... See more keywords
First Case Report of a Uterine Angiolipoleiomyoma With KRAS and KIT Mutations
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DOI: 10.1097/pgp.0000000000000842
Abstract: Angiolipoleiomyoma is a very rare lesion of the uterus. To the best of our knowledge, only 20 cases have been described in the literature. It is an insufficiently defined entity, which is not included in… read more here.
Keywords: kras kit; case report; case; angiolipoleiomyoma ... See more keywords
Abstract 812: New c-KIT mutations in GISTs: Bad for good
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DOI: 10.1158/1538-7445.am2018-812
Abstract: Gastrointestinal stromal tumors are mesenchymal tumors arising in the stomach and small bowel and more rarely in the rectum, esophagus, peritoneum and retroperitoneum. These tumors are characterized by KIT or PDGFRA mutations. KIT mutations are… read more here.
Keywords: new kit; mutations gists; gists bad; kit ... See more keywords
Mutated KIT Tyrosine Kinase as a Novel Molecular Target in Acute Myeloid Leukemia
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DOI: 10.3390/ijms23094694
Abstract: KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells. Since KIT is activated by overexpression or mutation and plays an important role in the development of some cancers, such… read more here.
Keywords: myeloid leukemia; kit; acute myeloid; tyrosine kinase ... See more keywords