Malignancies associated with GIST: a retrospective study with molecular analysis of KIT and PDGFRA
Sign Up to like & getrecommendations! Published in 2019 at "Langenbeck's Archives of Surgery"
DOI: 10.1007/s00423-019-01773-2
Abstract: PurposeGastrointestinal stromal tumors (GISTs) are the most common soft tissue tumors of the GI tract. Studies have been published reporting additional neoplasms in GIST patients. This study aimed to evaluate possible associations of mutation type,… read more here.
Keywords: kit pdgfra; associated gist; study; malignancies associated ... See more keywords
Abstract 3925: Inhibition of oncogenic and drug-resistant PDGFRA and KIT alterations by DCC-2618
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3925
Abstract: Introduction: Activating mutations and other genetic alterations in KIT and PDGFRA receptor tyrosine kinases have been identified in certain cancers and proliferative diseases, including most cases of gastrointestinal stromal tumors (GIST) and systemic mastocytosis, and… read more here.
Keywords: kit pdgfra; pdgfra kit; drug resistant; kit ... See more keywords
The KIT/PDGFRA Inhibitor Ripretinib Shows Signs of Activity in GIST.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-124
Abstract: The overall response rate was 19.4% in patients who received ripretinib as a second-line therapy. read more here.
Keywords: signs activity; ripretinib shows; shows signs; inhibitor ripretinib ... See more keywords
Tropomyosin-Related Kinase Fusions in Gastrointestinal Stromal Tumors
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DOI: 10.3390/cancers14112659
Abstract: Simple Summary The canonical mutations in gastrointestinal stromal tumors (GISTs) are typically activating mutations in KIT and platelet-derived growth factor receptor alpha (PDGFRA). Imatinib, the treatment of choice for GISTs, shows a lower response in… read more here.
Keywords: fusion; pdgfra wild; kit pdgfra; pdgfra ... See more keywords
Integrated Antitumor Activities of Cellular Immunotherapy with CIK Lymphocytes and Interferons against KIT/PDGFRA Wild Type GIST
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810368
Abstract: Gastrointestinal stromal tumors (GISTs) are rare, mesenchymal tumors of the gastrointestinal tract, characterized by either KIT or PDGFRA mutation in about 85% of cases. KIT/PDGFRA wild type gastrointestinal stromal tumors (wtGIST) account for the remaining… read more here.
Keywords: immunotherapy; cik; pdgfra wild; ifn ... See more keywords
Mutational Analysis of c-KIT and PDGFRA in Canine Gastrointestinal Stromal Tumors (GISTs)
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Sciences"
DOI: 10.3390/vetsci9070376
Abstract: Simple Summary Gastrointestinal stromal tumors represent the most common mesenchymal tumor of the canine gastrointestinal tract. Activating mutations in c-KIT and PDGFRA genes are considered the key molecular drivers of human gastrointestinal stromal tumors pathogenesis… read more here.
Keywords: stromal tumors; kit; canine gastrointestinal; kit pdgfra ... See more keywords