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Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.1c01090
Abstract: Cryogenic electron microscopy (cryo-EM) has emerged as a viable structural tool for molecular therapeutics development against human diseases. However, it remains a challenge to determine structures of proteins that are flexible and smaller than 30…
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Keywords:
kix;
acute myeloid;
myeloid leukemia;
protein ... See more keywords
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2
Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl4618
Abstract: EP300, a transcription coactivator important in proliferation and differentiation, is frequently mutated in diverse cancer types, including small cell lung cancer (SCLC). While these mutations are thought to result in loss of EP300 function, the…
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Keywords:
cell;
ep300;
domain;
kix domain ... See more keywords
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1
Published in 2020 at "BMC Biology"
DOI: 10.1186/s12915-020-00886-1
Abstract: Background CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous transcription factors potentially affecting expression of thousands of genes. Identifying specific domain functions for…
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Keywords:
cbp kix;
kix;
memory;
kix domain ... See more keywords
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Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009977
Abstract: The coactivator KIX of CBP uses two binding surfaces to recognize multiple activators and exhibits allostery in ternary complex formation. Activator•coactivator interactions are central to transcriptional regulation, yet the microscopic origins of allostery in dynamic…
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Keywords:
allostery dynamic;
molecular recognition;
coactivator;
micro states ... See more keywords