Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia
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DOI: 10.1021/acscentsci.1c01090
Abstract: Cryogenic electron microscopy (cryo-EM) has emerged as a viable structural tool for molecular therapeutics development against human diseases. However, it remains a challenge to determine structures of proteins that are flexible and smaller than 30… read more here.
Keywords: kix; acute myeloid; myeloid leukemia; protein ... See more keywords
KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer
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DOI: 10.1126/sciadv.abl4618
Abstract: EP300, a transcription coactivator important in proliferation and differentiation, is frequently mutated in diverse cancer types, including small cell lung cancer (SCLC). While these mutations are thought to result in loss of EP300 function, the… read more here.
Keywords: cell; ep300; domain; kix domain ... See more keywords
The CBP KIX domain regulates long-term memory and circadian activity
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DOI: 10.1186/s12915-020-00886-1
Abstract: Background CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous transcription factors potentially affecting expression of thousands of genes. Identifying specific domain functions for… read more here.
Keywords: cbp kix; kix; memory; kix domain ... See more keywords