Differential proteomic analysis of white adipose tissues from T2D KKAy mice by LC‐ESI‐QTOF
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600219
Abstract: Type 2 diabetes (T2D) has become a worldwide increasingly social health burden for its high morbidity and heightened prevalence. As one of the main tissues involved in uptake of glucose under the stimulation of insulin,… read more here.
Keywords: kkay mice; differential proteomic; proteomic analysis; t2d kkay ... See more keywords
Terminal differentiation of keratinocytes was damaged in type 2 diabetic mice.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07367-4
Abstract: AIMS Although skin manifestations are common in diabetic patients, its characteristics are poorly identified. This study explored the differentiation process of keratinocytes in type 2 diabetes mellitus (T2DM) in vivo. METHODS Back skin of T2DM… read more here.
Keywords: differentiation; keratinocytes damaged; differentiation keratinocytes; terminal differentiation ... See more keywords
Saikokeishikankyoto extract alleviates muscle atrophy in KKAy mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-021-01590-2
Abstract: Sarcopenic obesity is associated with increased visceral fat and decreased muscle mass, resulting in decreased insulin sensitivity, increased production of inflammatory cytokines, and oxidative stress. In this study, we first evaluated the effects of herbal… read more here.
Keywords: kkay mice; saikokeishikankyoto; muscle; muscle atrophy ... See more keywords
Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-019-0311-z
Abstract: Osteocalcin, expressed in osteoblasts of the bone marrow, undergoes post-translational carboxylation and deposits in mineralized bone matrix. A portion of osteocalcin remains uncarboxylated (uncarboxylated osteocalcin, GluOC) that is released into blood where it functions as… read more here.
Keywords: insulin sensitivity; kkay; kkay mice;
Hypoglycemic and hypolipidaemic activities of polysaccharides from Rhodiola rosea in KKAy mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Food Processing and Preservation"
DOI: 10.1111/jfpp.13219
Abstract: Hyperglycaemia and hyperlipidaemia are major risk factors for developing coronary artery diseases and atherosclerosis; therefore, therapeutic drugs must be developed to prevent these conditions. Rhodiola rosea is widely used in traditional Chinese medicine. In this… read more here.
Keywords: hypolipidaemic activities; rhodiola rosea; rosea; kkay mice ... See more keywords
Co-Crystal of Rosiglitazone With Berberine Ameliorates Hyperglycemia and Insulin Resistance Through the PI3K/AKT/TXNIP Pathway In Vivo and In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.842879
Abstract: Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and hyperglycemia. This study examined the effect and elucidated the mechanism of improvement of hyperglycemia and insulin resistance by a… read more here.
Keywords: rosiglitazone; pi3k akt; insulin resistance; kkay mice ... See more keywords