Development of a scale‐up strategy for Chinese hamster ovary cell culture processes using the kLa ratio as a direct indicator of gas stripping conditions
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DOI: 10.1002/btpr.3000
Abstract: Herein, we described a scale‐up strategy focused on the dissolved carbon dioxide concentration (dCO2) during fed‐batch cultivation of Chinese hamster ovary cells. A fed‐batch culture process for a 2000‐L scale stainless steel (SS) bioreactor was… read more here.
Keywords: kla ratio; bioreactor; fed batch; dco2 ... See more keywords