The KLDpT activation loop motif is critical for MARK kinase activity
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DOI: 10.1371/journal.pone.0225727
Abstract: MAP/microtubule-affinity regulating kinases (MARK1-4) are members of the AMPK family of Ser/Thr-specific kinases, which phosphorylate substrates at consensus LXRXXSXXXL motifs. Within microtubule-associated proteins, MARKs also mediate phosphorylation of variant KXGS or ζXKXGSXXNΨ motifs, interfering with… read more here.
Keywords: loop motif; kldpt activation; kinase; activity ... See more keywords