Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cell research"
DOI: 10.1016/j.scr.2017.07.007
Abstract: Krueppel-like factor 15 (KLF15) is abundantly expressed in liver, kidney, and muscle, including myocardium. In the adult heart KLF15 is important to maintain homeostasis and to repress hypertrophic remodeling. We generated a homozygous hESC KLF15… read more here.
Keywords: using paired; paired crispr; line using; klf15 ... See more keywords
The Krüppel-Like Factor 15-NFATc1 Axis Ameliorates Podocyte Injury: A Novel Rationale for Using Glucocorticoids in Proteinuria Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20200075
Abstract: Podocyte injury and loss contribute to proteinuria, glomerulosclerosis and eventually kidney failure. Recent studies have demonstrated that the loss of Kruppel-like factor 15 (KLF15) in podocytes increases the susceptibility to injury; however, the mechanism underlying… read more here.
Keywords: klf15; like factor; nfatc1 axis; podocyte injury ... See more keywords
KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj2917
Abstract: Circulating corticosteroids orchestrate stress adaptation, including inhibition of inflammation. While pathways governing corticosteroid biosynthesis and intracellular signaling are well understood, less is known about mechanisms controlling plasma corticosteroid transport. Here, we show that hepatocyte KLF15… read more here.
Keywords: corticosteroid transport; plasma corticosteroid; inflammation; klf15 ... See more keywords
Krüppel-Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2015060672
Abstract: Podocyte injury is the inciting event in primary glomerulopathies, such as minimal change disease and primary FSGS, and glucocorticoids remain the initial and often, the primary treatment of choice for these glomerulopathies. Because inflammation is… read more here.
Keywords: klf15; podocyte differentiation; ppel like; factor ... See more keywords
MiR-376b-3p functions as a tumor suppressor by targeting KLF15 in non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202009_23033
Abstract: OBJECTIVE The aim of this study was to explore the regulatory effects of micro ribonucleic acid (miR)-376b-3p on proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells by targeting Kruppel-like factor 15 (KLF15) and… read more here.
Keywords: klf15; nsclc cells; mir 376b; cell ... See more keywords