Targeting CXCR4 to suppress glioma‐initiating cells and chemoresistance in glioma
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11836
Abstract: Glioma initiating cells (GICs), also known as glioma stem cells, display the capacity to recapitulate the functional diversity within the tumor. Despite the great progress achieved over the last decades, defining the key molecular regulators… read more here.
Keywords: cxcr4; klf5; glioma initiating; glioma ... See more keywords
miR‐145‐5p affects the differentiation of gastric cancer by targeting KLF5 directly
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27525
Abstract: Krüppel‐like factor 5 (KLF5) takes part in the pathologic processes of many types of cancer; however, its expression and roles in the biological behavior of gastric cancer remain unknown. TargetScan suggested that miR‐145‐5p is the… read more here.
Keywords: mir 145; gastric cancer; differentiation; expression ... See more keywords
HDAC-mediated deacetylation of KLF5 associates with its proteasomal degradation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.153
Abstract: Krüppel-like factor 5 (KLF5) is a basic transcription factor that regulates diverse cellular processes during tumor development. Acetylation of KLF5 at lysine 369 (K369) reverses its function from promoting to suppressing cell proliferation and tumor… read more here.
Keywords: degradation; acetylation; deacetylation; klf5 ... See more keywords
Identification and functional characterization of KLF5 as a novel disease gene responsible for familial dilated cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2019.103827
Abstract: As a prevalent primary myocardial disease, dilated cardiomyopathy (DCM) represents the most common cause of heart failure in the young and the most frequent indication for cardiac transplantation. Aggregating evidence highlights the genetic basis of… read more here.
Keywords: genetics; disease; klf5; dilated cardiomyopathy ... See more keywords
FoxF1 protects rats from paraquat-evoked lung injury following HDAC2 inhibition via the microRNA-342/KLF5/IκB/NF-κB p65 axis.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112208
Abstract: PURPOSE Forkhead box f1 (FoxF1), a transcription factor, was implicated in lung development. However, the molecular mechanism of FoxF1 in lung injury, specifically in injury caused by paraquat (PQ), one of the most frequently used… read more here.
Keywords: foxf1; inhibition; mir 342; klf5 ... See more keywords
A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01579-4
Abstract: BACKGROUND KLF5 plays a crucial role in stem cells of colorectum in cooperation with Lgr5 gene. In this study, we aimed to explicate a regulatory mechanism of the KLF5 gene product from a view of… read more here.
Keywords: three dimensional; dimensional genome; genome structure; klf5 ... See more keywords
Klf5 Mediates Odontoblastic Differentiation through Regulating Dentin-Specific Extracellular Matrix Gene Expression during Mouse Tooth Development
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46746
Abstract: Klf5, a member of the Krüppel-like transcription factor family, has essential roles during embryonic development, cell proliferation, differentiation, migration and apoptosis. This study was to define molecular mechanism of Klf5 during the odontoblastic differentiation. The… read more here.
Keywords: mouse tooth; differentiation; klf5; odontoblastic differentiation ... See more keywords
KLF5-mediated aquaporin 3 activated autophagy to facilitate cisplatin resistance of gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2122498
Abstract: Abstract Background Resistance to chemotherapeutic drugs limits the control of gastric cancer (GC) development. The study intended to probe into the mechanism of aquaporin 3 (AQP3) on the chemoresistance of GC. Methods Cisplatin (CDDP)-resistant cells… read more here.
Keywords: cddp resistant; resistant cells; cddp; klf5 ... See more keywords
P1196AN INIHIBITOR OF KRUPPEL-LIKE FACTOR 5 SUPPRESSES PERITONEAL FIBROSIS IN MICE
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p1196
Abstract: We presented previously that Am80, a synthetic retinoic acid receptor α specific agonist, inhibited the expression of Krüppel-like transcription factor 5 (KLF5) and reduced peritoneal fibrosis in mice. Now, we examined further detail about the… read more here.
Keywords: peritoneal fibrosis; fibrosis; fibrosis mice; klf5 ... See more keywords
Inhibiting Intestinal Krüppel-Like Factor 5 Impairs the Beneficial Role of Renal Denervation in Gut Microbiota in Rats with Heart Failure
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02183-22
Abstract: Krüppel-like factor 5 (KLF5) is critical for the maintenance of intestinal barrier function. It is unclear whether intestinal KLF5 expression can be affected by renal denervation (RDN) in heart failure (HF) and whether inhibiting intestinal… read more here.
Keywords: gut microbiota; role; expression; intestinal klf5 ... See more keywords
Kruppel Like Factor 5 Enhances High Glucose-Induced Renal Tubular Epithelial Cell Transdifferentiation in Diabetic Nephropathy.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2022043565
Abstract: Background - Diabetic nephropathy (DN) is a principal reason for kidney disease worldwide. High glucose (HG) is a major factor for DN. Kruppel like factor 5 (KLF5) participates in DN development. In the present study,… read more here.
Keywords: cell; transdifferentiation; factor; klf5 ... See more keywords