CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation.
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DOI: 10.1038/s41418-021-00890-0
Abstract: The cystine/glutamate antiporter SLC7A11 (commonly known as xCT) functions to import cystine for glutathione biosynthesis, thereby protecting cells from oxidative stress and ferroptosis, a regulated form of non-apoptotic cell death driven by the accumulation of… read more here.
Keywords: crl2 klhdc3; p14arf; ubiquitin ligase; klhdc3 ... See more keywords