Kallikrein-related peptidase 6 (KLK6) expression differentiates tumor subtypes and predicts clinical outcome in breast cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-018-0487-4
Abstract: Novel molecular markers that address the heterogeneity of breast cancer (BC) and provide meaningful prognostic information for BC patients are needed. Kallikrein-related peptidase 6 (KLK6) is aberrantly expressed and functionally implicated in BC and, like… read more here.
Keywords: klk6 expression; outcome; breast cancer; klk6 ... See more keywords
A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07378
Abstract: Pancreatic cancer has the lowest survival rate of all common cancers due to late diagnosis and limited treatment options. Serine hydrolases are known to mediate cancer progression and metastasis through initiation of signaling cascades and… read more here.
Keywords: pancreatic cancer; activity; activity based; klk6 ... See more keywords
Scalable synthesis and structural characterization of reversible KLK6 inhibitors
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DOI: 10.1039/d2ra04670a
Abstract: Scalable asymmetric syntheses of two kallikrein-related protease 6 (KLK6) inhibitors are reported. The inhibitors are assembled by linking enantiomerically enriched fragments via amide bond formation, followed by conversion of a cyano group to an amidine.… read more here.
Keywords: characterization reversible; synthesis structural; klk6 inhibitors; scalable synthesis ... See more keywords
KLK6 protease accelerates skin tumor formation and progression
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DOI: 10.1093/carcin/bgy110
Abstract: Kallikrein-related peptidase 6 (KLK6) is a serine protease that is aberrantly altered in various types of cancer, but its role in non-melanoma skin cancer has not been investigated. KLK6 is active in epidermis and has… read more here.
Keywords: protease; skin; klk6; skin tumor ... See more keywords
KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in Bladder Urothelial Carcinoma
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DOI: 10.1155/2022/3373851
Abstract: Background Kallikrein-related peptidase 6 (KLK6) has been substantiated as a diagnostic, prognostic, and therapeutic molecular in several cancer types. In our study, we attempt to explore the biological functions of KLK6 in bladder urothelial carcinoma… read more here.
Keywords: bladder urothelial; expression; urothelial carcinoma; klk6 ... See more keywords