Association of serum Klotho levels with cancer and cancer mortality: Evidence from National Health and Nutrition Examination Survey
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5027
Abstract: Klotho has both anticancer and hormone‐like functions. But the research on Klotho and cancer is mainly based on animal experiments and small‐scale clinical research, thus we explored the association between serum Klotho and cancer and… read more here.
Keywords: cancer mortality; serum klotho; klotho; association serum ... See more keywords
Overexpression of HOTAIR attenuates Pi-induced vascular calcification by inhibiting Wnt/β-catenin through regulating miR-126/Klotho/SIRT1 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04164-8
Abstract: Vascular calcification is one of the most common effects of macrovascular complications in patients in aging with chronic kidney disease and diabetes. Previous studies showed that HOTAIR attenuated vascular calcification via the Wnt/β-catenin-signaling pathway, yet… read more here.
Keywords: vascular calcification; mir 126; hotair; calcification ... See more keywords
Exercise Training Attenuates Cardiac Vulnerability and Promotes Cardiac Resistance to Isoproterenol-Induced Injury Following Hookah Smoke Inhalation in Male Rats: Role of Klotho and Sirtuins.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular toxicology"
DOI: 10.1007/s12012-022-09733-x
Abstract: Hookah smoking is on the rise around the world. Present study investigated the heart resistance to harmful stress following long-term waterpipe tobacco smoking (WTS) and moderate-intensity exercise training intervention in male Wistar rats. Animals were… read more here.
Keywords: hookah smoke; resistance; heart; klotho ... See more keywords
Klotho at the Edge of Alzheimer’s Disease and Senile Depression
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1200-z
Abstract: Klotho, encoded by the KL gene, is a single-pass transmembrane protein and a circulating factor that plays a key role in cellular metabolism and body homeostasis and has been associated with age-related diseases. Alterations of… read more here.
Keywords: depression; alzheimer disease; klotho edge; edge alzheimer ... See more keywords
The Emerging Key Role of Klotho in the Hypothalamus–Pituitary–Ovarian Axis
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00277-5
Abstract: The hypothalamus–pituitary–ovary axis is the most important system for regulating female reproductive endocrine function. Its dysfunction would lead to the abnormal secretion of gonadotropin-releasing hormone, follicle-stimulating hormone, or luteinizing hormone, and eventually result in the… read more here.
Keywords: axis; hypothalamus pituitary; klotho; key role ... See more keywords
Klotho down-regulates Egr-1 by inhibiting TGF-β1/Smad3 signaling in high glucose treated human mesangial cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.04.036
Abstract: Diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease worldwide and is associated with glomerular mesangial cell (MC) proliferation and excessive extracellular matrix (ECM) production. Klotho can attenuate renal fibrosis in… read more here.
Keywords: high glucose; smad3; smad3 signaling; expression ... See more keywords
FGF23-Klotho signaling axis in the kidney.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2016.09.010
Abstract: Fibroblast growth factor-23 (FGF23) is a bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney. The kidney is one… read more here.
Keywords: fgf23 klotho; klotho signaling; klotho; renal tubules ... See more keywords
Effects of klotho deletion from bone during chronic kidney disease.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2017.02.006
Abstract: Klotho is a type I transmembrane protein that acts as a permissive co-receptor for FGF23 and helps to maintain proper mineral metabolism. Mice carrying a loss-of-function mutation in either the Klotho or Fgf23 gene develop… read more here.
Keywords: effects klotho; klotho fgf23; deletion bone; bone ... See more keywords
Elevated Fibroblast Growth Factor 23 and Decreased Klotho Levels Are Associated With Diastolic Dysfunction in CKD G4–5D Patients
Sign Up to like & getrecommendations! Published in 2020 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2020.04.022
Abstract: To the Editor: In a recent study, Sharma et al. reported an association between higher levels of fibroblast growth factor 23 (FGF-23) and left ventricular (LV) diastolic dysfunction in 47 end-stage renal disease (ESRD) patients… read more here.
Keywords: fibroblast growth; growth factor; klotho levels; klotho ... See more keywords
Intermedin alleviates pathological cardiac remodeling by upregulating klotho.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104926
Abstract: Cardiac remodeling is accompanied by cardiac hypertrophy, fibrosis, dysfunction, and eventually leading to heart failure. Intermedin (IMD), as a paracrine/autocrine peptide, has a protective effect in cardiovascular diseases. In this study, we elucidated the role… read more here.
Keywords: imd; upregulating klotho; cardiac remodeling; mice ... See more keywords
Identification of Small-Molecule Inhibitors of Fibroblast Growth Factor 23 Signaling via In Silico Hot Spot Prediction and Molecular Docking to α-Klotho
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00633
Abstract: Fibroblast growth factor 23 (FGF23) is a therapeutic target for treating hereditary and acquired hypophosphatemic disorders, such as X-linked hypophosphatemic (XLH) rickets and tumor-induced osteomalacia (TIO), respectively. FGF23-induced hypophosphatemia is mediated by signaling through a… read more here.
Keywords: hot spot; small molecule; fibroblast growth; klotho ... See more keywords