Acute lung injury complicating acute kidney injury: A model of endogenous αKlotho deficiency and distant organ dysfunction.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2017.03.047
Abstract: The lung interfaces with atmospheric oxygen via a large surface area and is perfused by the entire venous return bearing waste products collected from the whole body. It is logical that the lung is endowed… read more here.
Keywords: acute kidney; injury; klotho deficiency; lung ... See more keywords
In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101692
Abstract: Objective Klotho is an aging-suppressor gene which leads to accelerated aging when disrupted. This study was designed to investigate whether glutathione reductase (GR), a critical intracellular antioxidant enzyme, is involved in the pathogenesis of kidney… read more here.
Keywords: kidney; klotho deficiency; gene; glutathione ... See more keywords
MicroRNA 379 Regulates Klotho Deficiency–Induced Cardiomyocyte Apoptosis Via Repression of Smurf1
Sign Up to like & getrecommendations! Published in 2021 at "Hypertension"
DOI: 10.1161/hypertensionaha.120.16888
Abstract: Supplemental Digital Content is available in the text. Klotho is an aging-suppressor gene. Klotho gene deficiency impairs heart function leading to heart failure, but the underlying mechanism remains poorly understood. MicroRNAs are increasingly recognized to… read more here.
Keywords: cardiomyocyte apoptosis; klotho deficiency; apoptosis; deficiency induced ... See more keywords