Upregulation of PRMT6 by LPS suppresses Klotho expression through interaction with NF‐κB in glomerular mesangial cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26511
Abstract: Lipopolysaccharide (LPS) released from gram‐negative bacteria stimulates immune responses in infected cells. Epigenetic modifications such as DNA methylation and protein methylation modulate LPS‐induced innate immune gene expressions. Expression of the Klotho protein decreased with LPS… read more here.
Keywords: protein; methylation; prmt6; mes cells ... See more keywords
Epigenetic modifications of Klotho expression in kidney diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-021-02044-8
Abstract: Developments of many renal diseases are substantially influenced by epigenetic modifications of numerous genes, mainly mediated by DNA methylations, histone modifications, and microRNA interference; however, not all gene modifications causally affect the disease onset or… read more here.
Keywords: modifications klotho; epigenetic modifications; kidney diseases; expression kidney ... See more keywords
Inhibition of P2X7 receptor delays the progression of diabetic nephropathy and represses klotho expression
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.093
Abstract: Introduction Previous studies in our laboratory have suggested that P2X7 could contribute to the progression of diabetic nephropathy and modulate klotho expression. Aim of this study was to investigate the role of P2X7 knockdown in… read more here.
Keywords: p2x7; progression diabetic; diabetic nephropathy; klotho expression ... See more keywords
α-Klotho expression determines nitric oxide synthesis in response to FGF-23 in human aortic endothelial cells
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DOI: 10.1371/journal.pone.0176817
Abstract: Endothelial cells (ECs) express fibroblast growth factor (FGF) receptors and are metabolically active after treatment with FGF-23. It is not known if this effect is α-Klotho independent or mediated by humoral or endogenous endothelial α-Klotho.… read more here.
Keywords: fgf; endothelial cells; klotho expression; nitric oxide ... See more keywords
Partial Genetic Deletion of Klotho Aggravates Cardiac Calcium Mishandling in Acute Kidney Injury
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021322
Abstract: Acute kidney injury (AKI) is associated with an elevated risk of cardiovascular major events and mortality. The pathophysiological mechanisms underlying the complex cardiorenal network interaction remain unresolved. It is known that the presence of AKI… read more here.
Keywords: aki; deletion klotho; acute kidney; kidney injury ... See more keywords