Mutational landscape and clinical outcome of pediatric acute myeloid leukemia with 11q23/ KMT2A rearrangements
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DOI: 10.1002/cam4.5026
Abstract: Alterations of 11q23/KMT2A are the most prevalent cytogenetic abnormalities in acute myeloid leukemia (AML) and the prognostic significance of 11q23/KMT2A‐rearranged AML based on various translocation partners varies among different studies. However, few studies evaluated the… read more here.
Keywords: myeloid leukemia; 11q23 kmt2a; acute myeloid; kmt2a ... See more keywords
KMT2A‐D pathogenicity, prevalence, and variation according to a population database
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DOI: 10.1002/cam4.5443
Abstract: The KMT2 family of genes is essential epigenetic regulators promoting gene expression. The gene family contains three subgroups, each with two paralogues: KMT2A and KMT2B; KMT2C and KMT2D; KMT2F and KMT2G. KMT2A‐D are among the… read more here.
Keywords: kmt2a pathogenicity; kmt2a; prevalence variation; variation ... See more keywords
Establishment and characterization of a DOT1L inhibitor‐sensitive human acute monocytic leukemia cell line YBT‐5 with a novel KMT2A‐MLLT3 fusion
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.2686
Abstract: Immortalized cell lines are useful for deciphering the pathogenesis of acute leukemia and developing novel therapeutic agents against this malignancy. In this study, a new human myeloid leukemia cell line YBT‐5 was established. After more… read more here.
Keywords: ybt; cell line; leukemia; kmt2a ... See more keywords
De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
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DOI: 10.1038/s41467-018-04180-1
Abstract: Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate… read more here.
Keywords: signaling mutations; clonal evolution; kmt2a mllt3; kmt2a ... See more keywords
Comparison of minimal residual disease measurement by multicolour flow cytometry and PCR for fusion gene transcripts in infants with acute lymphoblastic leukaemia with KMT2A gene rearrangements.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of haematology"
DOI: 10.1111/bjh.18021
Abstract: This study aimed to evaluate the concordance between minimal residual disease (MRD) results obtained by multicolour flow cytometry (MFC) and polymerase chain reaction for fusion gene transcripts (FGTs) in infants with acute lymphoblastic leukaemia (ALL)… read more here.
Keywords: minimal residual; fusion; leukaemia; kmt2a ... See more keywords
A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Cytogenetic and Genome Research"
DOI: 10.1159/000499640
Abstract: Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. However, for patients with a KMT2A rearrangement (KMT2A-r), the prognosis appears to depend on the fusion partner gene rather than… read more here.
Keywords: myeloid leukemia; der; acute myeloid; fusion ... See more keywords
Tight Regulation of H3K79 Methylation Levels in KMT2A-Rearranged AML
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-114784
Abstract: Rationale: KMT2A-rearrangements (KMT2A-r) in acute myeloid leukemia (AML), encompassing both KMT2a-fusions (KMT2A-F) and KMT2A-partial tandem duplications (KMT2A-PTD), represent a subgroup of AML with a particularly poor prognosis. Both KMT2A-F and KMT2A-PTD share a dependency on… read more here.
Keywords: methylation; midh1; h3k79 methylation; kmt2a ... See more keywords
Outcome of (Novel) Subgroups in 1257 Pediatric Patients with KMT2A-Rearranged Acute Myeloid Leukemia (AML) and the Significance of Minimal Residual Disease (MRD) Status: A Retrospective Study By the I-BFM-SG
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DOI: 10.1182/blood-2020-136064
Abstract: Introduction Outcome of KMT2A-rearranged (KMT2A-r) pediatric AML (pAML) is in general poor with a 5-year probability of event-free survival (5y-pEFS) and overall survival (5y-pOS) of 44% and 56%, respectively (Balgobind et al., 2009). However, over… read more here.
Keywords: q23; mrd; induction course; q23 0001 ... See more keywords
Outcomes of Acute Lymphoblastic Leukemia with KMT2A (MLL) rearrangement - The MD Anderson Experience.
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DOI: 10.1182/bloodadvances.2021004580
Abstract: Acute lymphoblastic leukemia (ALL) with t(4;11)(q21;q23) - KMT2A-AFF1 is associated with a poor prognosis. The impact of KMT2A rearrangements other than t(4;11) is uncertain and the benefit of allogeneic stem cell transplant (HSCT) is unclear.… read more here.
Keywords: lymphoblastic leukemia; rate; acute lymphoblastic; outcomes acute ... See more keywords
Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation
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DOI: 10.18632/oncotarget.18668
Abstract: Glioblastomas are among the most fatal brain tumors; however, the molecular determinants of their tumorigenic behavior are not adequately defined. In this study, we analyzed the role of KMT2A in the glioblastoma cell line U-87… read more here.
Keywords: cell proliferation; kmt2a; notch1 notch3; proliferation ... See more keywords
Novel Diagnostic and Therapeutic Options for KMT2A-Rearranged Acute Leukemias
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.749472
Abstract: The KMT2A (MLL) gene rearrangements (KMT2A-r) are associated with a diverse spectrum of acute leukemias. Although most KMT2A-r are restricted to nine partner genes, we have recently revealed that KMT2A-USP2 fusions are often missed during… read more here.
Keywords: novel diagnostic; acute leukemias; inhibitor; acute leukemia ... See more keywords