Mutational landscape and clinical outcome of pediatric acute myeloid leukemia with 11q23/ KMT2A rearrangements
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DOI: 10.1002/cam4.5026
Abstract: Alterations of 11q23/KMT2A are the most prevalent cytogenetic abnormalities in acute myeloid leukemia (AML) and the prognostic significance of 11q23/KMT2A‐rearranged AML based on various translocation partners varies among different studies. However, few studies evaluated the… read more here.
Keywords: myeloid leukemia; 11q23 kmt2a; acute myeloid; kmt2a ... See more keywords
KMT2A‐D pathogenicity, prevalence, and variation according to a population database
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DOI: 10.1002/cam4.5443
Abstract: The KMT2 family of genes is essential epigenetic regulators promoting gene expression. The gene family contains three subgroups, each with two paralogues: KMT2A and KMT2B; KMT2C and KMT2D; KMT2F and KMT2G. KMT2A‐D are among the… read more here.
Keywords: kmt2a pathogenicity; kmt2a; prevalence variation; variation ... See more keywords
Type B3 Thymoma With a Novel KMT2A::MAML3 Fusion: Expanding the Spectrum of Gene Fusions Beyond the MAML2 Gene
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DOI: 10.1002/gcc.70071
Abstract: Mastermind‐like transcriptional coactivator (MAML) gene fusions have been documented in Thymic Epithelial Tumors (TETs). Specifically, lysine methyltransferase 2A (KMT2A)::MAML2 gene fusions are associated with type B2 and B3 thymomas. Here, we report for the first… read more here.
Keywords: thymoma; fusion; maml3; gene fusions ... See more keywords
Establishment and characterization of a DOT1L inhibitor‐sensitive human acute monocytic leukemia cell line YBT‐5 with a novel KMT2A‐MLLT3 fusion
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.2686
Abstract: Immortalized cell lines are useful for deciphering the pathogenesis of acute leukemia and developing novel therapeutic agents against this malignancy. In this study, a new human myeloid leukemia cell line YBT‐5 was established. After more… read more here.
Keywords: ybt; cell line; leukemia; kmt2a ... See more keywords
Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
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DOI: 10.1002/ijc.35332
Abstract: Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation… read more here.
Keywords: lessons learned; menin kmt2a; leukemia; kmt2a interaction ... See more keywords
De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
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DOI: 10.1038/s41467-018-04180-1
Abstract: Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate… read more here.
Keywords: signaling mutations; clonal evolution; kmt2a mllt3; kmt2a ... See more keywords
Comparison of minimal residual disease measurement by multicolour flow cytometry and PCR for fusion gene transcripts in infants with acute lymphoblastic leukaemia with KMT2A gene rearrangements.
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DOI: 10.1111/bjh.18021
Abstract: This study aimed to evaluate the concordance between minimal residual disease (MRD) results obtained by multicolour flow cytometry (MFC) and polymerase chain reaction for fusion gene transcripts (FGTs) in infants with acute lymphoblastic leukaemia (ALL)… read more here.
Keywords: minimal residual; fusion; leukaemia; kmt2a ... See more keywords
Enhancer‐activated RET confers protection against oxidative stress to KMT2A‐rearranged acute myeloid leukemia
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DOI: 10.1111/cas.16069
Abstract: Ectopic activation of rearranged during transfection (RET) has been reported to facilitate lineage differentiation and cell proliferation in different cytogenetic subtypes of acute myeloid leukemia (AML). Herein, we demonstrate that RET is significantly (p read more here.
Keywords: acute myeloid; aml; kmt2a aml; kmt2a ... See more keywords
Abstract A008: Epigenetic dynamics in KMT2A-amplified leukemia
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DOI: 10.1158/1538-7445.dnamethylation-a008
Abstract: The lysine methyltransferase KMT2A/MLL1 plays a crucial role in normal development and hematopoiesis. Rearrangement of KMT2A results in the formation of a KMT2A fusion protein with aberrant activity, which is a well-characterized driver of leukemogenesis… read more here.
Keywords: epigenetic dynamics; kmt2a amplified; dynamics kmt2a; kmt2a amplification ... See more keywords
A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia
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DOI: 10.1159/000499640
Abstract: Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. However, for patients with a KMT2A rearrangement (KMT2A-r), the prognosis appears to depend on the fusion partner gene rather than… read more here.
Keywords: myeloid leukemia; der; acute myeloid; fusion ... See more keywords
Tight Regulation of H3K79 Methylation Levels in KMT2A-Rearranged AML
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DOI: 10.1182/blood-2018-99-114784
Abstract: Rationale: KMT2A-rearrangements (KMT2A-r) in acute myeloid leukemia (AML), encompassing both KMT2a-fusions (KMT2A-F) and KMT2A-partial tandem duplications (KMT2A-PTD), represent a subgroup of AML with a particularly poor prognosis. Both KMT2A-F and KMT2A-PTD share a dependency on… read more here.
Keywords: methylation; midh1; h3k79 methylation; kmt2a ... See more keywords