De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04180-1
Abstract: Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate… read more here.
Keywords: signaling mutations; clonal evolution; kmt2a mllt3; kmt2a ... See more keywords
A case of KMT2A‐MLLT3 fusion‐positive mature B‐cell acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Pediatrics International"
DOI: 10.1111/ped.14477
Abstract: duced cardiomyopathy because of the persistence of VT, which was at a relatively low heart rate with no accompanying palpitations, rather than frequent PVCs. We should pay attention to cardiac symptoms such as syncope, palpitations,… read more here.
Keywords: case kmt2a; ablation; successfully ablated; psc ... See more keywords