Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac121
Abstract: Kabuki syndrome (KS) is frequently caused by loss-of-function mutations in one allele of the H3K4 methyltransferase KMT2D and is associated with problems in neurological, immunological, and skeletal system development. We generated heterozygous KMT2D knock-out and… read more here.
Keywords: cell; stem cell; methyltransferase kmt2d; kmt2d ... See more keywords
Abstract 366: Association of MLL2/KMT2D and MLL3/KMT2C with chronic myeloid leukemia
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DOI: 10.1158/1538-7445.am2018-366
Abstract: Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm linked to the Philadelphia chromosome presence that generates the BCR-ABL1 fusion oncogene. Tyrosine kinase inhibitors (TKI) such as imatinib mesylate (IM) dramatically improved the treatment efficiency… read more here.
Keywords: mll2 kmt2d; kmt2d mll3; kmt2d; mll3 kmt2c ... See more keywords
Histone Methyltransferase KMT2D Regulates H3K4 Methylation and is Involved in the Pathogenesis of Ovarian Cancer
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DOI: 10.1177/09636897211027521
Abstract: To investigate the function of histone-lysine N-methyltransferase 2D (KMT2D) on the methylation of H3 lysine 4 (H3K4) in the progression of Ovarian cancer (OV). KMT2D, ESR1 and H3K4me expressions in surgical resected tumors and tumor… read more here.
Keywords: kmt2d; h3k4me; methyltransferase kmt2d; ovarian cancer ... See more keywords