Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome.
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DOI: 10.1172/jci.insight.129375
Abstract: Chromatin modifiers act to coordinate gene expression changes critical to neuronal differentiation from neural stem/progenitor cells (NSPCs). Lysine-specific methyltransferase 2D (KMT2D) encodes a histone methyltransferase that promotes transcriptional activation, and is frequently mutated in cancers… read more here.
Keywords: oxygen; kmt2d deficient; kabuki syndrome; precocious neuronal ... See more keywords