Conditional deletion of KOR (Oprk1) in kisspeptin cells does not alter LH pulses, puberty, or fertility in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac175
Abstract: Classic pharmacological studies suggested that endogenous dynorphin-KOR signaling is important for reproductive neuroendocrine regulation. With the seminal discovery of an interconnected network of hypothalamic arcuate neurons co-expressing kisspeptin, neurokinin B, and dynorphin ("KNDy neurons"), the… read more here.
Keywords: kisspeptin cells; hypothesis; kisspeptin; kndy neurons ... See more keywords
SAT-426 Rabies-Mediated Monosynaptic Tract-Tracing of Sexually Dimorphic Estrogen-Sensitive Afferents to KNDy Neurons in the Mouse
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-426
Abstract: Abstract Estradiol controls reproductive status and sexual behavior by acting upon a variety of neurochemical systems in the brain to mediate the sexually dimorphic release of gonadotrophins. However, the neural pathways that transmit steroid hormone… read more here.
Keywords: tract tracing; microscopy; sexually dimorphic; rabies mediated ... See more keywords
Long-term effects of prenatal undernutrition on female rat hypothalamic KNDy neurons
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine Connections"
DOI: 10.1530/ec-22-0307
Abstract: The nutritional environment during development periods induces metabolic programming, leading to metabolic disorders and detrimental influences on human reproductive health. This study aimed to determine the long-term adverse effect of intrauterine malnutrition on the reproductive… read more here.
Keywords: long term; kndy neurons; term; gene expression ... See more keywords
Regulation of GnRH pulsatility in ewes.
Sign Up to like & getrecommendations! Published in 2018 at "Reproduction"
DOI: 10.1530/rep-18-0127
Abstract: Early work in ewes provided a wealth of information on the physiological regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by internal and external inputs. Identification of the neural systems involved, however, was limited by the… read more here.
Keywords: gnrh; kndy neurons; gnrh pulse; kisspeptin ... See more keywords