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   Articles with "knock" as a keyword



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Construction of a sensitive pyrogen‐testing cell model by site‐specific knock‐in of multiple genes

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recommendations! Published in 2019 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.27084

Abstract: A pyrogen test is crucial for evaluating the safety of drugs and medical equipment, especially those involved in injections. As existing pyrogen tests, including the rabbit pyrogen test, the limulus amoebocyte lysate (LAL) test and… read more here.

Keywords: pyrogen; knock; cell model; test ... See more keywords
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Evaluation of Gene Expression Knock‐Down by Chemically and Structurally Modified Gapmer Antisense Oligonucleotides

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recommendations! Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202200168

Abstract: We analyzed the effect of modified nucleotides within gapmer antisense oligonucleotides on RNase H mediated gene silencing. Additionally, short hairpins were introduced into antisense oligonucleotides as structural motifs, and their influence on biological and physicochemical… read more here.

Keywords: knock; antisense oligonucleotides; gene; gapmer antisense ... See more keywords
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Generation of B6‐Ddx4em1(CreERT2)Utr, a novel CreERT2 knock‐in line, for germ cell lineage by CRISPR/Cas9

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recommendations! Published in 2020 at "genesis"

DOI: 10.1002/dvg.23367

Abstract: Germ cell development is essential for maintaining reproduction in animals. In postpubertal females, oogenesis is a highly complicated event for producing fertilizable oocytes. It starts when dormant primordial oocytes undergo activation to become growing oocytes.… read more here.

Keywords: creert2 utr; germ cell; creert2; knock ... See more keywords
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An effective double gene knock‐in strategy using small‐molecule L755507 in the medaka fish (Oryzias latipes)

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recommendations! Published in 2022 at "genesis"

DOI: 10.1002/dvg.23465

Abstract: Homology‐directed repair (HDR)‐mediated genome editing has become a powerful method for altering chromosomal sequences in a seamless and accurate manner. However, the low efficiency of HDR in most cells hinders the establishment of desired strains… read more here.

Keywords: knock; small molecule; hdr mediated; molecule l755507 ... See more keywords
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Dentoalveolar Defects of Hypophosphatasia are Recapitulated in a Sheep Knock‐In Model

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recommendations! Published in 2022 at "Journal of Bone and Mineral Research"

DOI: 10.1002/jbmr.4666

Abstract: Hypophosphatasia (HPP) is the inherited error‐of‐metabolism caused by mutations in ALPL, reducing the function of tissue‐nonspecific alkaline phosphatase (TNAP/TNALP/TNSALP). HPP is characterized by defective skeletal and dental mineralization and is categorized into several clinical subtypes… read more here.

Keywords: dentoalveolar defects; cementum; knock; bone ... See more keywords
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Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene

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recommendations! Published in 2019 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.24493

Abstract: Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in HD mouse models were generated such that HdhQ150 mice have an… read more here.

Keywords: knock; htt; splicing mutant; mice ... See more keywords
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Geosmin synthase ges1 knock‐down by siRNA in the dikaryotic fungus Tricholoma vaccinum

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recommendations! Published in 2021 at "Journal of Basic Microbiology"

DOI: 10.1002/jobm.202100564

Abstract: Genetic manipulation for generating knock‐out experiments is essential in deciphering the precise function of a gene. However, dikaryotic fungi pose the inherent challenge of having two allelic versions of each gene, one in each nucleus.… read more here.

Keywords: tricholoma vaccinum; dikaryotic fungus; knock; geosmin ... See more keywords
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Editing of Endogenous Genes in Cellular Immunotherapies

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recommendations! Published in 2020 at "Current Hematologic Malignancy Reports"

DOI: 10.1007/s11899-020-00587-0

Abstract: Purpose of Review T cell-based cellular and antibody immunotherapies have dramatically altered the landscape of cancer treatment over the past decade. Over the same time span, gene editing technologies have enabled unprecedented degrees of genetic… read more here.

Keywords: knock; cell; endogenous genes; editing endogenous ... See more keywords
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A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes.

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recommendations! Published in 2021 at "Molecular neurobiology"

DOI: 10.1007/s12035-021-02610-8

Abstract: Spinocerebellar ataxia type 3 is the most common autosomal dominant inherited ataxia worldwide, caused by a CAG repeat expansion in the Ataxin-3 gene resulting in a polyglutamine (polyQ)-expansion in the corresponding protein. The disease is… read more here.

Keywords: knock; sca3; disease; model ... See more keywords
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The potential of statistical RANS to predict knock tendency: Comparison with LES and experiments on a spark-ignition engine

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recommendations! Published in 2019 at "Applied Energy"

DOI: 10.1016/j.apenergy.2019.04.093

Abstract: Abstract Pollutant regulations and fuel consumption concerns are the driving guidelines for increased thermal efficiency and specific power in current internal combustion engines. The achievement of such challenging tasks in Spark Ignition units is often… read more here.

Keywords: statistical rans; knock; potential statistical; spark ignition ... See more keywords
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Fuel property effects on knock propensity and thermal efficiency in a direct-injection spark-ignition engine

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recommendations! Published in 2021 at "Applied Energy"

DOI: 10.1016/j.apenergy.2019.114221

Abstract: Abstract Engine knock remains one of the major barriers to further improvement in thermal efficiency of Direct-Injection Spark-Ignition (DISI) engines. While Research Octane Number and Motor Octane Number are often used as standard rating methods… read more here.

Keywords: knock; engine; thermal efficiency; fuel ... See more keywords