Desmin Knock-Out Cardiomyopathy: A Heart on the Verge of Metabolic Crisis
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DOI: 10.3390/ijms231912020
Abstract: Desmin mutations cause familial and sporadic cardiomyopathies. In addition to perturbing the contractile apparatus, both desmin deficiency and mutated desmin negatively impact mitochondria. Impaired myocardial metabolism secondary to mitochondrial defects could conceivably exacerbate cardiac contractile… read more here.
Keywords: cardiomyopathy heart; desmin; knock cardiomyopathy; creatine kinase ... See more keywords