The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2953
Abstract: The morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as… read more here.
Keywords: knock mice; senile plaque; plaque morphological; morphological differences ... See more keywords
Imaging of Tissue-Specific and Temporal Activation of GPCR Signaling Using DREADD Knock-In Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9121-1_21
Abstract: Engineered G protein-coupled receptors (DREADDs, designer receptors exclusively activated by designer drugs) are convenient tools for specific activation of GPCR signaling in many cell types. DREADDs have been utilized as research tools to study numerous… read more here.
Keywords: gpcr signaling; activation gpcr; knock mice; mice ... See more keywords
Functional validation of epitope-tagged ATF5 knock-in mice generated by improved genome editing of oviductal nucleic acid delivery (i-GONAD).
Sign Up to like & getrecommendations! Published in 2021 at "Cell and tissue research"
DOI: 10.1007/s00441-021-03450-7
Abstract: Activating transcription factor 5 (ATF5) is a stress-responsive transcription factor that belongs to the cAMP response element-binding protein (CREB)/ATF family, and is essential for the differentiation and survival of sensory neurons in murine olfactory organs.… read more here.
Keywords: protein; genome editing; knock mice; functional validation ... See more keywords
Deletion of the sodium/hydrogen exchanger 6 causes low bone volume in adult mice.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116178
Abstract: The sodium/hydrogen exchanger 6 (NHE6) localizes to recycling endosomes, where it mediates endosomal alkalinization through K+/H+ exchange. Mutations in the SLC9A6 gene encoding NHE6 cause severe X-linked mental retardation, epilepsy, autism and corticobasal degeneration in… read more here.
Keywords: knock mice; nhe6 knock; bone; mice ... See more keywords
Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12565-z
Abstract: Xanthine oxidoreductase has been implicated in cancer. Nonetheless, the role played by its two convertible forms, xanthine dehydrogenase (XDH) and oxidase (XO) during tumorigenesis is not understood. Here we produce XDH-stable and XO-locked knock-in (ki)… read more here.
Keywords: tumor; knock mice; xdh; growth ... See more keywords
Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18691-3
Abstract: Somatic mutations in the calreticulin (CALR) gene are associated with approximately 30% of essential thrombocythemia (ET) and primary myelofibrosis (PMF). CALR mutations, including the two most frequent 52 bp deletion (del52) and 5 bp insertion (ins5), induce… read more here.
Keywords: phenotypes observed; knock mice; del52; del52 ins5 ... See more keywords
NaV1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49392-7
Abstract: Mutations of the SCN2A gene, encoding the voltage gated sodium channel NaV1.2, have been associated to a wide spectrum of epileptic disorders ranging from benign familial neonatal-infantile seizures to early onset epileptic encephalopathies such as… read more here.
Keywords: scn2a mice; knock mice; autistic like; scn2a ... See more keywords
New technique for knock-in mice
Sign Up to like & getrecommendations! Published in 2018 at "Lab Animal"
DOI: 10.1038/s41684-018-0126-4
Abstract: In eukaryotes, small ubiquitin-like modifier (SUMO) is a protein family with four different isoforms (S1 to S4) that has enzymes dedicated to conjugating SUMO to target proteins. SUMOylation impacts enzyme location and function and has… read more here.
Keywords: knock mice; cell; new technique; technique knock ... See more keywords
Lacrimal Gland and Orbital Lesions in LatY136F Knock-in Mice, a Model for Human IgG4-Related Ophthalmic Disease
Sign Up to like & getrecommendations! Published in 2022 at "Current Eye Research"
DOI: 10.1080/02713683.2022.2103152
Abstract: Abstract Purpose LatY136F knock-in mice were recently proposed as an animal model for immunoglobulin G4 (IgG4)-related disease. In this study, we investigated whether LatY136F knock-in mice exhibit ophthalmic lesions, specifically in the lacrimal and Harderian… read more here.
Keywords: laty136f knock; igg1 positive; harderian glands; knock mice ... See more keywords
Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz091
Abstract: Abstract Alcohol consumption is the key risk factor for the development of esophageal squamous cell carcinoma (ESCC), and acetaldehyde, a metabolite of alcohol, is an alcohol-derived major carcinogen that causes DNA damage. Aldehyde dehydrogenase2 (ALDH2)… read more here.
Keywords: dna damage; knock mice; alcohol; aldh2 ... See more keywords
Paradoxical electro-olfactogram responses in TMEM16B knock-out mice.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical senses"
DOI: 10.1093/chemse/bjad003
Abstract: The Ca 2+-activated Cl¯ channel TMEM16B carries up to 90% of the transduction current evoked by odorant stimulation in olfactory sensory neurons and control the number of action potential firing and therefore the length of… read more here.
Keywords: tmem16b knock; knock mice; electro olfactogram; eog responses ... See more keywords