Generation and characterization of an estrogen receptor alpha‐iCre knock‐in mouse
Sign Up to like & getrecommendations! Published in 2017 at "genesis"
DOI: 10.1002/dvg.23084
Abstract: Two estrogen receptors, ESR1 and ESR2, are responsible for the classical actions of estrogens in mammalian species. They display different spatiotemporal expression patterns and nonoverlapping functions in various tissues and physiological conditions. In this study,… read more here.
Keywords: estrogen; knock mouse; icre; characterization ... See more keywords
TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
Sign Up to like & getrecommendations! Published in 2018 at "Nature neuroscience"
DOI: 10.1038/s41593-018-0113-5
Abstract: Amyotrophic lateral sclerosis–frontotemporal dementia (ALS-FTD) constitutes a devastating disease spectrum characterized by 43-kDa TAR DNA-binding protein (TDP-43) pathology. Understanding how TDP-43 contributes to neurodegeneration will help direct therapeutic efforts. Here we have created a TDP-43… read more here.
Keywords: autoregulation; tardbp; als ftd; knock mouse ... See more keywords
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm6155
Abstract: We previously developed single App knock-in mouse models of Alzheimer’s disease (AD) that harbor the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation (AppNL-G-F and AppNL-F mice). We have now generated App knock-in… read more here.
Keywords: knock; mice; knock mouse; app knock ... See more keywords
Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01938-7
Abstract: Background Elevated blood homocysteine levels, termed hyperhomocysteinemia (HHcy), is a prevalent risk factor for Alzheimer’s disease (AD) in elderly populations. While dietary supplementation of B-vitamins is a generally effective method to lower homocysteine levels, there… read more here.
Keywords: alzheimer disease; pathology; knock mouse; hyperhomocysteinemia ... See more keywords
Characterization of a Knock-In Mouse Line Expressing a Fusion Protein of κ Opioid Receptor Conjugated with tdTomato: 3-Dimensional Brain Imaging via CLARITY
Sign Up to like & getrecommendations! Published in 2020 at "eNeuro"
DOI: 10.1523/eneuro.0028-20.2020
Abstract: Abstract Activation of κ opioid receptor (KOR) produces analgesia, antipruritic effect, sedation and dysphoria. To characterize neuroanatomy of KOR at high resolutions and circumvent issues of specificity of KOR antibodies, we generated a knock-in mouse… read more here.
Keywords: mouse line; opioid receptor; line expressing; brain ... See more keywords
Characterization of two novel knock-in mouse models of syndromic retinal ciliopathy carrying hypomorphic Sdccag8 mutations
Sign Up to like & getrecommendations! Published in 2022 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2021.387
Abstract: Mutations in serologically defined colon cancer autoantigen protein 8 (SDCCAG8) were first identified in retinal ciliopathy families a decade ago with unknown function. To investigate the pathogenesis of SDCCAG8-associated retinal ciliopathies in vivo, we employed… read more here.
Keywords: knock; mouse; sdccag8; retinal ciliopathy ... See more keywords
Knock-In Mouse Models to Investigate the Functions of Opioid Receptors in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.807549
Abstract: Due to their low expression levels, complex multi-pass transmembrane structure, and the current lack of highly specific antibodies, the assessment of endogenous G protein-coupled receptors (GPCRs) remains challenging. While most of the research regarding their… read more here.
Keywords: knock; mouse; investigate functions; models investigate ... See more keywords