PO-142 RNAi-mediated therapeutic knockdown of the neuropilin axis and GIPC1 in pancreatic carcinoma
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DOI: 10.1136/esmoopen-2018-eacr25.183
Abstract: Introduction Pancreatic ductal adenocarcinoma (PDAC) is associated with a 5 year survival rate of less than 4%, indicating the often poor success rate of chemotherapy and the need for novel treatment strategies based on targeted therapies.… read more here.
Keywords: knockdown; gipc1; neuropilin axis; inhibition ... See more keywords
AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing’s sarcoma cells
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DOI: 10.1371/journal.pone.0269077
Abstract: Ewing’s sarcoma is the second most common bone malignancy in children or young adults and is caused by an oncogenic transcription factor by a chromosomal translocation between the EWSR1 gene and the ETS transcription factor… read more here.
Keywords: transcriptional activity; ewing sarcoma; knockdown; sarcoma cells ... See more keywords