Regional knockdown of NDUFS4 implicates a thalamocortical circuit mediating anesthetic sensitivity
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DOI: 10.1371/journal.pone.0188087
Abstract: Knockout of the mitochondrial complex I protein, NDUFS4, profoundly increases sensitivity of mice to volatile anesthetics. In mice carrying an Ndufs4lox/lox gene, adeno-associated virus expressing Cre recombinase was injected into regions of the brain postulated… read more here.
Keywords: knockdown ndufs4; association cortex; sensitivity; parietal association ... See more keywords