Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity.
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DOI: 10.1016/j.chembiol.2020.03.010
Abstract: α-Synuclein (α-syn) overload is strongly associated with Parkinson disease (PD), and reduction of the α-syn level by targeting the peptide-based system through the autophagy-lysosomal pathway (ALP) is a promising strategy to delay PD progression. However,… read more here.
Keywords: degradation; syn; knockdown synuclein; proteasome degradation ... See more keywords