Holocarboxylase synthetase knockout is embryonic lethal in mice
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DOI: 10.1371/journal.pone.0265539
Abstract: Holocarboxylase synthetase (HLCS) catalyzes the biotinylation of five distinct biotin-dependent carboxylases and perhaps chromatin proteins. HLCS deficiency causes multiple carboxylase deficiency which results in fatal consequences unless patients are diagnosed early and treated with pharmacological… read more here.
Keywords: knockout embryonic; knockout; embryonic lethal; holocarboxylase synthetase ... See more keywords