Mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice with age-related hearing loss.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13655
Abstract: Previous studies have revealed that age-related hearing loss (AHL) in Cdk5 regulatory subunit associated protein 1 (Cdk5rap1)-knockout mice is associated with pathology in the cochlea. Here, we aimed to identify mitochondrial alterations in the cochlea… read more here.
Keywords: cdk5rap1 knockout; knockout mice; hearing loss; loss ... See more keywords
Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice.
Sign Up to like & getrecommendations! Published in 2023 at "Brain and behavior"
DOI: 10.1002/brb3.3075
Abstract: INTRODUCTION Sleep abnormalities are highly correlated with neurodevelopmental disorders, such as intellectual disability, attention deficit hyperactivity disorder, and autism spectrum disorders (ASD). The severity of behavioral abnormalities is correlated with the presence of sleep abnormalities.… read more here.
Keywords: sleep restriction; chronic sleep; ctnnd2 knockout; effects chronic ... See more keywords
Mu and delta opioid receptor knockout mice show increased colonic sensitivity
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pain"
DOI: 10.1002/ejp.965
Abstract: Opiates act through opioid receptors to diminish pain. Here, we investigated whether mu (MOR) and delta (DOR) receptor endogenous activity assessed in the whole mouse body or in particular at peripheral receptors on primary nociceptive… read more here.
Keywords: opioid receptor; knockout mice; delta opioid; receptor ... See more keywords
4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12412
Abstract: Sarcopenia is the loss of muscle mass/function that occurs during the aging process. The links between mechanistic target of rapamycin (mTOR) activity and muscle development are largely documented, but the role of its downstream targets… read more here.
Keywords: bp2 double; bp1 bp2; muscle; knockout mice ... See more keywords
Diet‐Induced Obesity in Cannabinoid‐2 Receptor Knockout Mice and Cannabinoid Receptor 1/2 Double‐Knockout Mice
Sign Up to like & getrecommendations! Published in 2019 at "Obesity"
DOI: 10.1002/oby.22403
Abstract: Evidence suggests that cannabinoid‐1 receptor (CB1R) activation is associated with increased food intake and body weight gain. Human epidemiological studies, however, show decreased prevalence of obesity in cannabis users. Given the overlapping and complementary functions… read more here.
Keywords: knockout mice; cannabinoid receptor; mice;
Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03238-7
Abstract: Claudins are a family of integral tight junction proteins that regulate paracellular permeability in polarized epithelia. Overexpression or reduction of claudins can both promote and limit cancer progression, revealing complex dichotomous roles for claudins depending… read more here.
Keywords: knockout mice; cancer; roles claudins; dichotomous roles ... See more keywords
Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular medicine"
DOI: 10.1007/s00109-020-01974-z
Abstract: Fibulin-3 (F3) is an extracellular matrix glycoprotein found in basement membranes across the body. An autosomal dominant R345W mutation in F3 causes a macular dystrophy resembling dry age-related macular degeneration (AMD), whereas genetic removal of… read more here.
Keywords: knockout mice; mice; fibulin; retina rpe ... See more keywords
Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4820-7
Abstract: Background and AimDiabetes is the main cause of gastroparesis accompanying decreased neuronal nitric oxide synthase (nNOS) in myenteric ganglia of the stomach. Decreased nNOS expression in the stomach also results from defects in apolipoprotein E… read more here.
Keywords: enteric glial; knockout mice; apoe knockout; gastric emptying ... See more keywords
Increase of Hspa1a and Hspa1b genes in the resting B cells of Sirt1 knockout mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04876-7
Abstract: Sirt1, also known as the longevity gene, is an NAD+-dependent class III histone deacetylase that has been extensively studied in multiple areas of research including cellular metabolism, longevity, cancer, autoimmunity, and immunity. However, little is… read more here.
Keywords: hspa1a hspa1b; resting cells; knockout mice; increase hspa1a ... See more keywords
Dysregulation of humoral immunity in Foxp3 conditional-knockout mice.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.090
Abstract: Foxp3+ regulatory T cells (Tregs) are crucial for maintaining tolerance to self-antigens and preventing autoimmune diseases. Loss of Foxp3 expression leads to autoimmunity and disrupts humoral immune responses, including hyperproduction of immunoglobulin E (IgE). Elucidation… read more here.
Keywords: foxp3floxr26creert2 mice; humoral immunity; knockout mice; mice ... See more keywords
Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.01.026
Abstract: BACKGOUND Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice… read more here.
Keywords: connectivity; alcohol; knockout mice; mice ... See more keywords