Mouse Knockout Models for Pelvic Organ Prolapse: a Systematic Review
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DOI: 10.1007/s00192-021-05066-5
Abstract: Mouse knockout (KO) models of pelvic organ prolapse (POP) have contributed mechanistic evidence for the role of connective tissue defects, specifically impaired elastic matrix remodeling. Our objective was to summarize what mouse KO models for… read more here.
Keywords: pop; mouse; models pelvic; pelvic organ ... See more keywords
Inducible TDG knockout models to study epigenetic regulation.
Sign Up to like & getrecommendations! Published in 2020 at "F1000Research"
DOI: 10.12688/f1000research.25637.1
Abstract: Mechanistic and functional studies by gene disruption or editing approaches often suffer from confounding effects like compensatory cellular adaptations generated by clonal selection. These issues become particularly relevant when studying factors directly involved in genetic… read more here.
Keywords: escs; dna; tdg; knockout models ... See more keywords