Generation of an Armcx1 Conditional Knockout Mouse
Sign Up to like & getrecommendations! Published in 2024 at "genesis"
DOI: 10.1002/dvg.23615
Abstract: Armadillo repeat‐containing X‐linked protein‐1 (Armcx1) is a poorly characterized transmembrane protein that regulates mitochondrial transport in neurons. Its overexpression has been shown to induce neurite outgrowth in embryonic neurons and to promote retinal ganglion cell… read more here.
Keywords: generation armcx1; armcx1 conditional; conditional knockout; knockout mouse ... See more keywords
Gemini-based lipoplexes complement the mitochondrial phenotype in MFN1-Knockout mouse embryonic fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00449
Abstract: Mitochondria form a dynamic network of constantly dividing and fusing organelles. The balance between these antagonistic processes is crucial for normal cellular function and requires the action of specialized proteins. The mitochondrial membrane proteins Mitofusin… read more here.
Keywords: phenotype; mfn1; mfn1 knockout; embryonic fibroblasts ... See more keywords
A novel knockout mouse model to assess the impact of one-copy loss of Hnrnpk in CD4 + T cells in chronically inflamed skin as a prelude to CTCL
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-98640-6
Abstract: Cutaneous T-cell lymphomas (CTCLs), particularly Mycosis fungoides (MF), frequently exhibit deletions and reduced expression of HNRNPK in CD4 + T cells. To enable in vivo studies, we developed a conditional Hnrnpk knockout mouse that thrives, facilitating the… read more here.
Keywords: cd4 cells; hnrnpk; knockout mouse; hnrnpk cd4 ... See more keywords
The intricate dance of RNA-binding proteins: unveiling the mechanisms behind male infertility.
Sign Up to like & getrecommendations! Published in 2025 at "Human reproduction update"
DOI: 10.1093/humupd/dmaf023
Abstract: Abstract BACKGROUND RNA-binding proteins (RBPs) are indispensable for transcriptional and post-transcriptional processes during spermatogenesis, orchestrating germ cell proliferation, differentiation, and maturation. Despite their established importance, the contributions of RBPs in male infertility remain underexplored. Recently,… read more here.
Keywords: infertility; knockout mouse; male infertility; rbp genes ... See more keywords
NIH Knockout Mouse Phenotyping Program (KOMP2) and IMPC: Database to Discover New Roles of Genes in Cardiovascular Physiology and Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00011.2019
Abstract: The collaborative goal of NIH Knockout Mouse Phenotyping Program (KOMP2) and International Knockout Mouse Phenotyping Consortium (IMPC) is to discover functional insight for every gene in the mouse genome by 2021, by generating and systematically… read more here.
Keywords: physiology; gene; impc; knockout mouse ... See more keywords
Knockout mice with pituitary malformations help identify human cases of hypopituitarism
Sign Up to like & getrecommendations! Published in 2024 at "Genome Medicine"
DOI: 10.1186/s13073-024-01347-y
Abstract: Congenital hypopituitarism (CH) and its associated syndromes, septo-optic dysplasia (SOD) and holoprosencephaly (HPE), are midline defects that cause significant morbidity for affected people. Variants in 67 genes are associated with CH, but a vast majority… read more here.
Keywords: pituitary malformations; hypopituitarism; knockout mouse; candidate genes ... See more keywords
Developmental deficits of MGE-derived interneurons in the Cntnap2 knockout mouse model of autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1112062
Abstract: Interneurons are fundamental cells for maintaining the excitation-inhibition balance in the brain in health and disease. While interneurons have been shown to play a key role in the pathophysiology of autism spectrum disorder (ASD) in… read more here.
Keywords: cntnap2 knockout; autism spectrum; knockout mouse; knockout ... See more keywords
A Novel Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.696537
Abstract: Prostate cancer (PCa) is associated with advanced age, but how age contributes to prostate carcinogenesis remains unknown. The prostate-specific Pten conditional knockout mouse model closely imitates human PCa initiation and progression. To better understand how… read more here.
Keywords: prostate; knockout mouse; prostate cancer; model ... See more keywords
Knockout Mouse Models for Peroxiredoxins
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9020182
Abstract: Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain intracellular reactive oxygen species (ROS) homeostasis. The family members are expressed in most organisms and involved in various biological processes, such as cellular… read more here.
Keywords: cys; mouse models; models peroxiredoxins; knockout mouse ... See more keywords