Gemini-based lipoplexes complement the mitochondrial phenotype in MFN1-Knockout mouse embryonic fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00449
Abstract: Mitochondria form a dynamic network of constantly dividing and fusing organelles. The balance between these antagonistic processes is crucial for normal cellular function and requires the action of specialized proteins. The mitochondrial membrane proteins Mitofusin… read more here.
Keywords: phenotype; mfn1; mfn1 knockout; embryonic fibroblasts ... See more keywords
NIH Knockout Mouse Phenotyping Program (KOMP2) and IMPC: Database to Discover New Roles of Genes in Cardiovascular Physiology and Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00011.2019
Abstract: The collaborative goal of NIH Knockout Mouse Phenotyping Program (KOMP2) and International Knockout Mouse Phenotyping Consortium (IMPC) is to discover functional insight for every gene in the mouse genome by 2021, by generating and systematically… read more here.
Keywords: physiology; gene; impc; knockout mouse ... See more keywords
Developmental deficits of MGE-derived interneurons in the Cntnap2 knockout mouse model of autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1112062
Abstract: Interneurons are fundamental cells for maintaining the excitation-inhibition balance in the brain in health and disease. While interneurons have been shown to play a key role in the pathophysiology of autism spectrum disorder (ASD) in… read more here.
Keywords: cntnap2 knockout; autism spectrum; knockout mouse; knockout ... See more keywords
A Novel Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.696537
Abstract: Prostate cancer (PCa) is associated with advanced age, but how age contributes to prostate carcinogenesis remains unknown. The prostate-specific Pten conditional knockout mouse model closely imitates human PCa initiation and progression. To better understand how… read more here.
Keywords: prostate; knockout mouse; prostate cancer; model ... See more keywords
Knockout Mouse Models for Peroxiredoxins
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9020182
Abstract: Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain intracellular reactive oxygen species (ROS) homeostasis. The family members are expressed in most organisms and involved in various biological processes, such as cellular… read more here.
Keywords: cys; mouse models; models peroxiredoxins; knockout mouse ... See more keywords