211. A NOVEL P2X7 KNOCKOUT RAT IS NOT PROTECTED FROM EXPERIMENTAL GLOMERULONEPHRITIS OR VASCULITIS
Sign Up to like & getrecommendations! Published in 2019 at "Rheumatology"
DOI: 10.1093/rheumatology/kez061.026
Abstract: P2X7 is an ionotropic receptor activated by extracellular ATP which is expressed on immune cells including macrophages, dendritic cells and lymphocytes and is up-regulated on non-immune cells following injury. P2X7 has previously been shown to… read more here.
Keywords: p2x7; glomerulonephritis; novel p2x7; knockout rat ... See more keywords
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf2695
Abstract: Hundreds of pathogenic variants of mitochondrial DNA (mtDNA) have been reported to cause mitochondrial diseases, which still lack effective treatments. It is a huge challenge to install these mutations one by one. We repurposed the… read more here.
Keywords: rat; stop codon; premature stop; coding genes ... See more keywords
Evidence of Neurobiological Changes in the Presymptomatic PINK1 Knockout Rat.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Parkinson's disease"
DOI: 10.3233/jpd-171273
Abstract: BACKGROUND Genetic models of Parkinson's disease (PD) coupled with advanced imaging techniques can elucidate neurobiological disease progression, and can help identify early biomarkers before clinical signs emerge. PTEN-induced putative kinase 1 (PINK1) helps protect neurons… read more here.
Keywords: knockout rat; pink1 knockout; pink1; brain ... See more keywords
Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model
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DOI: 10.3390/pharmaceutics14112307
Abstract: Background: Organic anion transporter 1 (OAT1) and OAT3 have an overlapping spectrum of substrates such that one can exert a compensatory effect when the other is dysfunctional. As a result, the knockout of either OAT1… read more here.
Keywords: knockout rat; rat model; knockout; double knockout ... See more keywords