Serotonin and urocortin 1 in the dorsal raphe and Edinger–Westphal nuclei after early life stress in serotonin transporter knockout rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2016.10.072
Abstract: The interaction of early life stress (ELS) and the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) has been associated with increased risk to develop depression in later life. We have used the maternal separation paradigm… read more here.
Keywords: life stress; early life; knockout rats; knockout ... See more keywords
CRISPR/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat
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DOI: 10.1038/s41598-020-67594-2
Abstract: Thyroid hormone (TH) has long been believed to play a minor role in male reproduction. However, evidences from experimental model of thyrotoxicosis or hypothyroidism suggests its role in spermatogenesis. Cellular action of TH requires membrane… read more here.
Keywords: spermatogenesis; mct8; knockout rats; slc16a2 ... See more keywords
Design and construction of Carboxylesterase 2c Gene knockout Rats by CRISPR/Cas9.
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DOI: 10.2174/1389200224666230123140919
Abstract: BACKGROUND Carboxylesterase 2 (CES2) is mainly distributed in the human liver and gut, and plays an active role in the metabolic activation of many prodrugs and lipid metabolism. Although CES2 is of great significance, there… read more here.
Keywords: crispr cas9; ces2; carboxylesterase; gene knockout ... See more keywords
Developmental changes in brain activity of heterozygous Scn1a knockout rats
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2023.1125089
Abstract: Introduction Dravet syndrome (DS) is an infantile-onset developmental and epileptic encephalopathy characterized by an age-dependent evolution of drug-resistant seizures and poor developmental outcomes. Functional impairment of gamma-aminobutyric acid (GABA)ergic interneurons due to loss-of-function mutation of… read more here.
Keywords: brain activity; brain; scn1a knockout; activity ... See more keywords