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   Articles with "knockout zebrafish" as a keyword



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Nucleotide sugar profiles throughout development in wildtype and galt knockout zebrafish

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recommendations! Published in 2020 at "Journal of Inherited Metabolic Disease"

DOI: 10.1002/jimd.12265

Abstract: Nucleotide sugars (NS) are fundamental molecules in life and play a key role in glycosylation reactions and signal conduction. Several pathways are involved in the synthesis of NS. The Leloir pathway, the main pathway for… read more here.

Keywords: throughout development; knockout zebrafish; galt knockout; wildtype galt ... See more keywords

CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications

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recommendations! Published in 2019 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-019-03127-z

Abstract: The gene CNDP1 was associated with the development of diabetic nephropathy. Its enzyme carnosinase 1 (CN1) primarily hydrolyzes the histidine-containing dipeptide carnosine but other organ and metabolic functions are mainly unknown. In our study we… read more here.

Keywords: amino acid; alters amino; cndp1 knockout; weight gain ... See more keywords
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CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-25604-5

Abstract: Coordinated chromatin interactions between enhancers and promoters are critical for gene regulation. The architectural protein CTCF mediates chromatin looping and is enriched at the boundaries of topologically associating domains (TADs), which are sub-megabase chromatin structures.… read more here.

Keywords: ctcf knockout; gene expression; ctcf; gene ... See more keywords
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Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish.

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recommendations! Published in 2019 at "Endocrinology"

DOI: 10.1210/en.2019-00445

Abstract: Thyroid hormones (THs) are crucial regulators of glucose metabolism and insulin sensitivity. Moreover, inactivating mutations in type 2 deiodinase (DIO2), the major TH-activating enzyme, have been associated with type 2 diabetes mellitus (T2D) in both… read more here.

Keywords: glucose homeostasis; insulin; age; expression ... See more keywords

Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration

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recommendations! Published in 2022 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1009841

Abstract: Neural retina leucine zipper (NRL) is an essential gene for the fate determination and differentiation of the precursor cells into rod photoreceptors in mammals. Mutations in NRL are associated with the autosomal recessive enhanced S-cone… read more here.

Keywords: rod; retinal degeneration; nrl knockout; model ... See more keywords

The Abcc6a Knockout Zebrafish Model as a Novel Tool for Drug Screening for Pseudoxanthoma Elasticum

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.822143

Abstract: Pseudoxanthoma elasticum (PXE) is a multisystem ectopic mineralization disorder caused by pathogenic variants in the ABCC6 gene. Though complications of the disease can be treated, PXE itself remains currently intractable. A strategy for rapid and… read more here.

Keywords: abcc6a knockout; zebrafish model; pseudoxanthoma elasticum; mineralization ... See more keywords

vwa1 Knockout in Zebrafish Causes Abnormal Craniofacial Chondrogenesis by Regulating FGF Pathway

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recommendations! Published in 2023 at "Genes"

DOI: 10.3390/genes14040838

Abstract: Hemifacial microsomia (HFM), a rare disorder of first- and second-pharyngeal arch development, has been linked to a point mutation in VWA1 (von Willebrand factor A domain containing 1), encoding the protein WARP in a five-generation… read more here.

Keywords: vwa1 knockout; chondrogenesis; regulating fgf; fgf pathway ... See more keywords
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Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24076456

Abstract: DJ-1 is a redox sensitive protein with a wide range of functions related to oxidative stress protection. Mutations in the park7 gene, which codes for DJ-1 are associated with early onset familial Parkinson’s disease and… read more here.

Keywords: progressive motor; disease; parkinson disease; motor ... See more keywords
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Transcriptomics and Phenotypic Analysis of gpr56 Knockout in Zebrafish

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24097740

Abstract: The adhesion G-protein-coupled receptor is a seven-transmembrane receptor protein with a complex structure. Impaired GPR56 has been found to cause developmental damage to the human brain, resulting in intellectual disability and motor dysfunction. To date,… read more here.

Keywords: transcriptomics phenotypic; phenotypic analysis; gpr56 knockout; knockout zebrafish ... See more keywords