Organocatalytic Cascade Knoevenagel–Michael Addition Reactions: Direct Synthesis of Polysubstituted 2-Amino-4H-Chromene Derivatives
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DOI: 10.1007/s10562-019-03089-8
Abstract: In this report, we documented novel strategy for the synthesis of bioactive polysubstituted 2-amino-4H-chromine derivatives under a heterogeneous Al-MCM-41-LDH@APTES (ALAM) catalysis. A synthetic procedure is developed to prepare Al-MCM-41-LDH@APTES (ALAM) heterogeneous basic catalysts. Mesoporous Al-MCM-41… read more here.
Keywords: synthesis polysubstituted; michael addition; polysubstituted amino; addition reactions ... See more keywords
Oleylamine-catalyzed Tandem Knoevenagel/Michael Addition of 1,3-Cyclohexanediones with Aromatic Aldehydes
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DOI: 10.1007/s40242-018-7320-1
Abstract: A convenient and efficient method was developed for the synthesis of 2,2′-(arylmethylene)bis(3-hydrox- ycyclohex-2-enone) derivatives via the oleylamine-catalyzed tandem Knoevenagel/Michael addition reactions of aromatic aldehydes and cyclohexane-1,3-diones. This transformation proceeded without any metal catalyst in non-toxic… read more here.
Keywords: michael addition; catalyzed tandem; oleylamine catalyzed; tandem knoevenagel ... See more keywords
Tandem Knoevenagel–Michael reactions in aqueous diethylamine medium: A greener and efficient approach toward bis-dimedone derivatives
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DOI: 10.1016/j.arabjc.2014.04.008
Abstract: Abstract Diethylamine catalyzed tandem Knoevenagel–Michael reactions have been carried out in aqueous medium as an efficient, greener and cost effective process for the simple one-pot synthesis of bis-dimedone derivatives. Reaction of substituted aromatic aldehyde (1… read more here.
Keywords: bis dimedone; dimedone derivatives; tandem knoevenagel; dimedone ... See more keywords
Imidazolium ylide mediated tandem Knoevenagel–Michael–O-cyclization sequence for the synthesis of multi-substituted 4,5-dihydrofurans
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DOI: 10.1080/00397911.2020.1821226
Abstract: Abstract The stereoselective syntheses of novel trans-5-aroyl-2,4-diaryl-4,5-dihydrofuran-3-carbonitriles have been achieved via a one-pot, three-component tandem protocol involving aroyl acetonitriles, aromatic aldehydes, and imidazolium ylide in the presence of Et3N. Graphical Abstract read more here.
Keywords: mediated tandem; michael cyclization; tandem knoevenagel; imidazolium ylide ... See more keywords