Enantioselective Direct Synthesis of C3-Hydroxyalkylated Pyrrole via an Amine-Catalyzed Aldol/Paal-Knorr Reaction Sequence.
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DOI: 10.1021/acs.orglett.2c02922
Abstract: Creating functionality with chirality at position C3 of pyrrole is challenging. An operationally simple organocatalytic method has been developed to generate functionality with a chiral tertiary/quaternary stereocenter at position C3 of pyrrole. The process proceeds… read more here.
Keywords: paal knorr; reaction; amine catalyzed; knorr reaction ... See more keywords