Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling
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DOI: 10.1073/pnas.2207327119
Abstract: Significance The Wnt pathway is critical for regeneration of tissues such as lung, skin, and intestine. Using a cystine-knot peptide (CKP) drug-discovery platform, we identified a class of peptide agonists that bind to the Wnt… read more here.
Keywords: knot peptide; signaling; cystine knot; peptide agonists ... See more keywords