Know Your Model: Why mouse inbred strain contribution matters
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DOI: 10.1038/s41684-020-0525-1
Abstract: Strain contributions arising from the strain of origin and backcrosses can modify phenotypic severity and/or penetrance of mutant alleles in mouse models. read more here.
Keywords: inbred strain; strain contribution; mouse inbred; model mouse ... See more keywords
Know Your Model: The role of sex in phenotype penetrance and severity
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DOI: 10.1038/s41684-020-0616-z
Abstract: There’s growing evidence that sex-based differences can influence phenotypes beyond those directly related to the reproductive system; to fully understand a gene’s function, researchers should consider both male and female subjects. read more here.
Keywords: model role; sex phenotype; sex; role sex ... See more keywords