Knowledge‐based structural models of SARS‐CoV‐2 proteins and their complexes with potential drugs
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DOI: 10.1002/1873-3468.13806
Abstract: The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID‐19) caused by the novel coronavirus SARS‐CoV‐2 a pandemic. There is, however, no confirmed anti‐COVID‐19 therapeutic currently. In order to assist structure‐based discovery efforts… read more here.
Keywords: cov proteins; structural models; models sars; knowledge based ... See more keywords
A knowledge‐based approach to automated planning for hepatocellular carcinoma
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DOI: 10.1002/acm2.12219
Abstract: Abstract Purpose To build a knowledge‐based model of liver cancer for Auto‐Planning, a function in Pinnacle, which is used as an automated inverse intensity modulated radiation therapy (IMRT) planning system. Methods and Materials Fifty Tomotherapy… read more here.
Keywords: planning; liver; model; knowledge based ... See more keywords
An Automated knowledge‐based planning routine for stereotactic body radiotherapy of peripheral lung tumors via DCA‐based volumetric modulated arc therapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.13114
Abstract: Abstract Purpose To develop a knowledge‐based planning (KBP) routine for stereotactic body radiotherapy (SBRT) of peripherally located early‐stage non‐small‐cell lung cancer (NSCLC) tumors via dynamic conformal arc (DCA)‐based volumetric modulated arc therapy (VMAT) using the… read more here.
Keywords: dca plans; planning routine; dca; knowledge based ... See more keywords
Knowledge‐based planning in robotic intracranial stereotactic radiosurgery treatments
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DOI: 10.1002/acm2.13173
Abstract: Abstract Purpose To develop a knowledge‐based planning (KBP) model that predicts dosimetric indices and facilitates planning in CyberKnife intracranial stereotactic radiosurgery/radiotherapy (SRS/SRT). Methods Forty CyberKnife SRS/SRT plans were retrospectively used to build a linear KBP… read more here.
Keywords: based planning; intracranial stereotactic; model; kbp model ... See more keywords
Knowledge‐based planning for the radiation therapy treatment plan quality assurance for patients with head and neck cancer
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DOI: 10.1002/acm2.13614
Abstract: Abstract This study aimed to investigate the feasibility of using a knowledge‐based planning technique to detect poor quality VMAT plans for patients with head and neck cancer. We created two dose–volume histogram (DVH) prediction models… read more here.
Keywords: plan quality; quality assurance; prediction; planning ... See more keywords
The implementation of knowledge‐based planning with partial OAR contours for prostate radiotherapy
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DOI: 10.1002/acm2.70004
Abstract: Abstract Purpose Intra‐ and inter‐observer contour uncertainty is a continuous challenge in treatment planning for radiotherapy. Our proposed solution to address this challenge is the use of partial contours for treatment planning, focusing on uninvolved… read more here.
Keywords: treatment; knowledge based; partial contours; based planning ... See more keywords
An extension to the OVH concept for knowledge‐based dose volume histogram prediction in lung tumor volumetric‐modulated arc therapy
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.70090
Abstract: Abstract Purpose Volumetric‐modulated arc therapy (VMAT) treatment planning allows a compromise between a sufficient coverage of the planning target volume (PTV) and a simultaneous sparing of organs‐at‐risk (OARs). Particularly in the case of lung tumors,… read more here.
Keywords: prediction; volume histogram; lung; knowledge based ... See more keywords
Combined strategy of knowledge‐based rule selection and historical data percentile‐based range determination to improve an autoverification system for clinical chemistry test results
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DOI: 10.1002/jcla.24233
Abstract: Current autoverification, which is only knowledge‐based, has low efficiency. Regular historical data analysis may improve autoverification range determination. We attempted to enhance autoverification by selecting autoverification rules by knowledge and ranges from historical data. This… read more here.
Keywords: system; chemistry; historical data; autoverification ... See more keywords
Developing knowledge‐based planning for gynaecological and rectal cancers: a clinical validation of RapidPlan™
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DOI: 10.1002/jmrs.396
Abstract: To create and clinically validate knowledge‐based planning (KBP) models for gynaecologic (GYN) and rectal cancer patients. Assessment of ecologic generalisability and predictive validity of conventional planning versus single calculation KBP was reviewed against practical metrics… read more here.
Keywords: based planning; planning gynaecological; developing knowledge; knowledge based ... See more keywords
Knowledge-based quality control of organ delineations in radiation therapy.
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DOI: 10.1002/mp.15458
Abstract: PURPOSE To reduce the likelihood of errors in organ delineations used for radiotherapy treatment planning, a knowledge-based quality control (KBQC) system which discriminates between valid and anomalous delineations is developed. METHODS AND MATERIALS The KBQC… read more here.
Keywords: system; quality control; based quality; organ delineations ... See more keywords
Technical Note: Determining the applicability of a clinical knowledge-based learning model via prospective outlier detection.
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DOI: 10.1002/mp.15516
Abstract: BACKGROUND Knowledge-based planning (KBP) is increasingly implemented clinically because of its demonstrated ability to improve treatment planning efficiency and reduce plan quality variations. However, cases with large dose-volume histogram (DVH) prediction uncertainties may still need… read more here.
Keywords: technical note; knowledge; detection; model ... See more keywords