Biological functions of kojic acid and its derivatives in medicine, cosmetics, and food industry: Insights into health aspects
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200215
Abstract: This review traces the road leading to the demonstration of a variety of kojic acid chemical and biological properties. It illustrates the biological effects of several synthetic kojic acid derivatives. Besides the main capability of… read more here.
Keywords: kojic acid; health; acid derivatives; medicine ... See more keywords
Antioxidative and Anti-inflammatory Effects of Kojic Acid in Aβ-Induced Mouse Model of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02460-4
Abstract: Alzheimer's disease (AD) is a common cause of dementia that is clinically characterized by the loss of memory and cognitive functions. Currently, there is no specific cure for the management of AD, although natural compounds… read more here.
Keywords: alzheimer disease; effects kojic; kojic acid; mouse model ... See more keywords
1,2,3-Triazole-based kojic acid analogs as potent tyrosinase inhibitors: Design, synthesis and biological evaluation.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.10.069
Abstract: A series of kojic acid-derived compounds 6a-p bearing aryloxymethyl-1H-1,2,3-triazol-1-yl moiety were designed by modifying primary alcoholic group of kojic acid as tyrosinase inhibitors. The target compounds 6a-p were synthesized via click reaction. All compounds showed… read more here.
Keywords: analogs potent; based kojic; tyrosinase inhibitors; kojic acid ... See more keywords
An allomaltol derivative triggers distinct death pathways in luminal a and triple-negative breast cancer subtypes.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104403
Abstract: Breast cancer is the most common cancer in women that shows a predisposition to metastasize to the distant organs. Kojic acid is a natural fungal metabolite exhibiting various biological activities. Compounds derived from kojic acid… read more here.
Keywords: death; allomaltol derivative; kojic acid; breast cancer ... See more keywords
The first efficient biocatalytic route for the synthesis of Kojic acid derivatives in aqueous media
Sign Up to like & getrecommendations! Published in 2021 at "Catalysis Communications"
DOI: 10.1016/j.catcom.2021.106289
Abstract: Abstract The first efficient biocatalytic route for the synthesis of kojic acid derivatives was developed in presence of an enzyme. In this process, benzaldehydes, malononitrile and kojic acid were used as starting materials while lipase… read more here.
Keywords: acid derivatives; efficient biocatalytic; first efficient; kojic acid ... See more keywords
Integrating transcriptomics and metabolomics analysis on kojic acid combating Acinetobacter baumannii biofilm and its potential roles.
Sign Up to like & getrecommendations! Published in 2021 at "Microbiological research"
DOI: 10.1016/j.micres.2021.126911
Abstract: As a major secondary metabolite derived from a dominant marine filamentous fungus A7, kojic acid might confer the strain a competitive advantage in natural colonization. The bioactivities of kojic acid against bacterial growth and biofilm… read more here.
Keywords: acid combating; biofilm formation; kojic acid; acinetobacter baumannii ... See more keywords
A new “Mitsunobu homocoupling” reaction using aldol adducts of kojic acid
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron"
DOI: 10.1016/j.tet.2021.132314
Abstract: Abstract In this study, we attempted to carry out the Mitsunobu 1,4-elimination using the kojic acid analog 3, which carries a hydroxymethyl group on C-6 introduced by aldol condensation, to obtain an effective Michael acceptor… read more here.
Keywords: new mitsunobu; homocoupling reaction; kojic acid; reaction ... See more keywords
Biological activities and safety data of kojic acid and its derivatives: A review
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Dermatology"
DOI: 10.1111/exd.14662
Abstract: Kojic acid presents a variety of applications for human use, especially as a depigmenting agent. Its derivatives are also proposed in order to prevent chemical degradation, prevent adverse effects and improve efficacy. The aim of… read more here.
Keywords: activities safety; activity; kojic acid; biological activities ... See more keywords
Antimicrobial Activity of Aspergillus sp. from the Amazon Biome: Isolation of Kojic Acid
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Microbiology"
DOI: 10.1155/2022/4010018
Abstract: The antimicrobial potential of Aspergillus sp., isolated from the Amazon biome, which is stored at the Amazon Fungi Collection-CFAM at ILMD/FIOCRUZ, was evaluated. The fungal culture was cultivated in yeast extract agar and sucrose (YES)… read more here.
Keywords: antimicrobial activity; activity aspergillus; activity; amazon biome ... See more keywords
Kojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0187351
Abstract: Mechanical damage can induce fruiting body production in fungi. In this study, the antioxidant kojic acid (KA) was found to enhance injured mycelial regeneration and increase fruiting body production in Hypsizygus marmoreus. KA reduced the… read more here.
Keywords: marmoreus; mycelial regeneration; regeneration; kojic acid ... See more keywords
Recent Advances in the Exploitation of Kojic Acid in Multicomponent Reactions
Sign Up to like & getrecommendations! Published in 2020 at "Current Organic Chemistry"
DOI: 10.2174/1385272824999200622113153
Abstract: Kojic acid, one of the most widespread 3-hydroxypyran-4-one derivatives, displays a wide range of biological activities and found application in food as well as cosmetics industry. The synthesis of kojic acid derivatives has provoked great… read more here.
Keywords: multicomponent reactions; chemistry; kojic acid; advances exploitation ... See more keywords